ID   MUTS_RHOP5              Reviewed;         906 AA.
AC   Q07V29;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RPE_0246;
OS   Rhodopseudomonas palustris (strain BisA53).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisA53;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y.,
RA   Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisA53.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000463; ABJ04205.1; -; Genomic_DNA.
DR   RefSeq; WP_011661699.1; NC_008435.1.
DR   AlphaFoldDB; Q07V29; -.
DR   SMR; Q07V29; -.
DR   STRING; 316055.RPE_0246; -.
DR   EnsemblBacteria; ABJ04205; ABJ04205; RPE_0246.
DR   KEGG; rpe:RPE_0246; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..906
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008083"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   906 AA;  97140 MW;  F31FA7120D29DDC9 CRC64;
     MTLQPAILSE PDTPAPAEAL TRVSPMMEQY HEIKAANPGL LLFYRMGDFY ELFFEDAEIA
     ARALGITLTK RGKHKGQDIP MCGVPVERSD DYLHRLIALG HRVAVCEQTE DPAAARARKS
     VVRRDVVRLI TPGTLTEDTL LDARTNNYLL AIARVRGSTG GDRLGLAWID ISTAEFIVTE
     CALGELAATL ARINPNEAIV TDALYSDPEL GPLLRELAAV TPLTRDVFDS ATAERRLCDY
     FAVATMDGLA AMSRLEATAA AACITYVERT QLGQKPPLSP PSREIAGATM AIDPATRANL
     ELTRTLAGER RGSLLDAIDC TVTAAGSRLL AQRLAAPLTD AGAIAHRLDA VEAFVADPIL
     RDGLRATLRA APDLARALAR LSVGRGGPRD LAALRDGLLA ADAALAQLAA ATSLPQEILA
     AMAALRRPSR QLADEFSRAL ADELPLQKRD GGFVRANYQA ALDETRALRD ASRQVVAAMQ
     ARYADAAGVK GLKIRHNNVL GYFVEVTAQH GERLMAAPMN ATFIHRQTLA GQVRFTTAEL
     GEIEAKIANA GERALGLELE IFEKLTAMVI AATDDLRAAA QAFATLDVTL ALAKLAIDDN
     YVRPEVDGSL SFAIEGGRHP VVEQALKRDG QPFIANACDL SPGPAQSSGQ IWLITGPNMA
     GKSTFLRQNA LIALLAQIGA FVPAARARIG IVDRLFSRVG AADDLARGRS TFMVEMVETA
     VILNQASERA LVILDEIGRG TATFDGLSIA WAAIEHLHES NRCRALFATH YHELTALSGK
     LPRVFNATVR VKEWHGEVVF LHEVMPGSAD RSYGIQVAKL AGLPPSVIAR AKTVLAKLEA
     NDRGQSARAL ADDLPLFALT ARAPAEALPP TEAEQLIAAL QALHPDELTP REALDALYAL
     KAKLPK