ID   MUTS_RHOPA              Reviewed;         907 AA.
AC   P61670;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RPA0512;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX572594; CAE25956.1; -; Genomic_DNA.
DR   RefSeq; WP_011156080.1; NC_005296.1.
DR   AlphaFoldDB; P61670; -.
DR   SMR; P61670; -.
DR   STRING; 258594.RPA0512; -.
DR   PRIDE; P61670; -.
DR   EnsemblBacteria; CAE25956; CAE25956; RPA0512.
DR   GeneID; 66891530; -.
DR   KEGG; rpa:RPA0512; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; P61670; -.
DR   BioCyc; RPAL258594:TX73_RS02655-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..907
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115128"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         656..663
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   907 AA;  97473 MW;  D65FCB2A16C42BA1 CRC64;
     MTIRPDIALP PDAAPPPEAP AKMSPMMEQY HEIKAANPGL LLFYRMGDFY ELFFEDAEIA
     SRALGITLTK RGKHLGADIP MCGVPVERSD DYLHRLIALG HRVAVCEQTE DPAAARARKS
     VVRRDVVRLI TPGTLTEDTL LDARANNYLL AIARARGSAG ADRIGLAWID ISTGEFCVTE
     CSTAELAATL ARINPNEAIV PDALYSDTEL APTLRELAAV TPLTRDVFDS ATAERRLCDY
     FAVATMDGLA ALSRLEATAA AACVTYVDRT QLGKRPPLSP PAREATGSTM AIDPATRANL
     ELTRTLAGER RGSLLDAIDC TVTAAGSRLL AQRLAAPLTD AATIARRLDA VEAFAVDSGL
     REQIRSSLRA APDMARALAR LSLGRGGPRD LANLRDGIRA ADEVLVQLAQ LASPPQEIAS
     AMAALQRPSR ELCAELGRAL ADDLPLLKRD GGFVREGYEP ALDETRKLRD ASRLVVASMQ
     ARYADDTGIK ALKIRHNNVL GYFVEVSAQH GEKLMAPPLN ATFIHRQTLA GQVRFTTAEL
     GEIEAKIANA GDRALGLELE IFDRLAGSID AAGDDLRAAA HAFALLDVAT ALAKLASDDN
     YVRPEVDESL AFAIEGGRHP VVEQALKRAG EPFIANACDL SPGPAQKNGQ IWLLTGPNMA
     GKSTFLRQNA LIALLAQVGS FVPAIRARIG IVDRLFSRVG AADDLARGRS TFMVEMVETA
     AILNQASERA LVILDEIGRG TATFDGLSIA WAAIEHLHEQ NRCRSLFATH YHELTALSAK
     LPRLFNATVR VKEWRGEVVF LHEVLPGSAD RSYGIQVAKL AGLPPSVVSR AKAVLAKLEA
     NDRGQPKTLI DDLPLFAITA RAPAEAAPPS EAEQLIDAVK ALHPDEMTPR EALDALYALK
     AKLPKAD