ID   MUTS_RHOPB              Reviewed;         905 AA.
AC   Q21CE8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RPC_0363;
OS   Rhodopseudomonas palustris (strain BisB18).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316056;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisB18;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S.,
RA   Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB18.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD85938.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000301; ABD85938.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041801273.1; NC_007925.1.
DR   AlphaFoldDB; Q21CE8; -.
DR   SMR; Q21CE8; -.
DR   STRING; 316056.RPC_0363; -.
DR   EnsemblBacteria; ABD85938; ABD85938; RPC_0363.
DR   KEGG; rpc:RPC_0363; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..905
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335214"
FT   REGION          272..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         654..661
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   905 AA;  97537 MW;  CEF7FA63FE308F1A CRC64;
     MSIEPDISPS PDTPAPIEAK VSPMMEQYHE IKAANPGLLL FYRMGDFYEL FFEDAEIAAR
     ALGITLTKRG KHKGQDIPMC GVPVERSDDY LHRLIALGHR VAVCEQTEDP AAARARKSVV
     RRDVVRLITP GTLTEDTLLD ARANNYLLAI ARARASAGAD RIGLAWIDIS TAEFIVTECA
     PAELAATLAR INPNEAIVTD ALYSDPELGP LLRELPAVTP LTRDVFDSAT AERRLCDYFA
     VATMDGLSAM SRLEATAAAA CVTYIDRTQL GKKPPLSPPS REATGSTMAI DPATRANLEL
     TRTLSGERRG SLLDAIDCTV TAAGSRLLAQ RLAAPLTDVE QIAQRLDAVA ALLPDPGLRE
     ALRATLRAAP DMSRALARLS VGRGGPRDLA ALRDGLLAAD QALAQLGALE VPPKEIQTAM
     AALRRPSRDL AQEFSRALAD DLPLMKRDGG FVREGYHDAL DETRKLRDDS RLIVAAMQAR
     YADDCGVKGL KIRHNNVLGY FVEVTAQHGD KLMAPPLNLT FIHRQTLAGQ TRFTTAELGE
     IEAKIANAGD RALGLELEIF ERLVALVQAA TDDLRAAAHG FAALDVTLAL AKLAVDDNYV
     RPEVDGSLSF AIEGGRHPVV EQALRRDGQP FIANACDLSP GPGQQSGQIW LITGPNMAGK
     STFLRQNALI ALLAQIGSFV PASRARIGIV DRLFSRVGAA DDLARGRSTF MVEMVETAVI
     LNQASERALV ILDEIGRGTA TFDGLSIAWA AIEHLHESNR CRSLFATHYH ELTALSAKLP
     RLFNATVRVK EWHGDVVFLH EVLPGSADRS YGIQVAKLAG LPPSVITRAK SVLAKLEAQD
     RGQSARALAE DLPLFAVTAR AAAEPSPPSE AERLIEALKA LHPDELSPRE ALDALYALKA
     KLGKA