ID   MUTS_RHOPS              Reviewed;         923 AA.
AC   Q13ED0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RPD_0321;
OS   Rhodopseudomonas palustris (strain BisB5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisB5;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S.,
RA   Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000283; ABE37559.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q13ED0; -.
DR   SMR; Q13ED0; -.
DR   STRING; 316057.RPD_0321; -.
DR   EnsemblBacteria; ABE37559; ABE37559; RPD_0321.
DR   KEGG; rpd:RPD_0321; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001818; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..923
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335215"
FT   BINDING         671..678
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   923 AA;  99051 MW;  F1BDA6B9C4F36D06 CRC64;
     MHRVMTIRPD IPPQPDIAAP AEPPARVSPM MEQYHEIKAA NPGLLLFYRM GDFYELFFED
     AEIASRALGI TLTKRGKHLG ADIPMCGVPV ERSDDYLHRL IALGHRVAVC EQTEDPAAAR
     ARKSVVRRDV VRLITPGTLT EDTLLDARAN NYLMAIARTR GSAGVDRIGL AWIDISTGEF
     CVTECATGEL SATLARINPN EAIVSDALYS DAELGPSLRE LAAVTPLTRD VFDSATAERR
     LCDYFAVATM DGLAALSRLE AAAAAACVTY VDRTQLGKRP PLSPPAREAA GATMAIDPAT
     RANLELTRTL GGERRGSLLD AIDCTVTAAG SRLLAQRLAA PLTDEAAIAR RLDAVAAFVA
     DSALREQIRS ALRAAPDMAR ALARLSLGRG GPRDLASLRD GVSAADKVLA QLSQLAQPPH
     DIAAAMAALR RPSRDLCQEL ARALADDLPL LKRDGGFVRD GYEAALDETR KLRDASRLVV
     AAMQARYADE TGVKGLKIRH NNVLGYFVEV TAQHGDRLMA PPLNATFIHR QTLAGQVRFT
     TAELGEIEAK IANAGDRALG LELDIFDRLA AMIDTAGDDL RAAAHAFALL DVATALAKLA
     VSDNYVRPEV DGSLAFAIEG GRHPVVEQAL KRAGEPFIAN ACDLSPVPPP FPPPLAGEGR
     VGAGQIWLLT GPNMAGKSTF LRQNALIALL AQTGSFVPAS RARIGIVDRL FSRVGAADDL
     ARGRSTFMVE MVETATILNQ ATERALVILD EIGRGTATFD GLSIAWAAIE HLHEQNRCRA
     LFATHYHELT ALSAKLPRLF NATVRVKEWR GEVVFLHEVL PGSADRSYGI QVAKLAGLPP
     SVVARAKSVL AKLEANDRGQ SARTLADDLP LFAMTARAPV EPPPPSEAEQ LIEAVRALHP
     DELSPREALD ALYALKAKLP KAD