ID   MUTS_RHORT              Reviewed;         929 AA.
AC   Q2RNG0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Rru_A3541;
OS   Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 /
OS   NCIMB 8255 / S1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Rhodospirillum.
OX   NCBI_TaxID=269796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1;
RX   PubMed=21886856; DOI=10.4056/sigs.1804360;
RA   Munk A.C., Copeland A., Lucas S., Lapidus A., Del Rio T.G., Barry K.,
RA   Detter J.C., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Kyrpides N.C.,
RA   Mavromatis K., Richardson P., Rohde M., Goeker M., Klenk H.P., Zhang Y.,
RA   Roberts G.P., Reslewic S., Schwartz D.C.;
RT   "Complete genome sequence of Rhodospirillum rubrum type strain (S1).";
RL   Stand. Genomic Sci. 4:293-302(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000230; ABC24335.1; -; Genomic_DNA.
DR   RefSeq; WP_011391288.1; NC_007643.1.
DR   RefSeq; YP_428622.1; NC_007643.1.
DR   AlphaFoldDB; Q2RNG0; -.
DR   SMR; Q2RNG0; -.
DR   STRING; 269796.Rru_A3541; -.
DR   PRIDE; Q2RNG0; -.
DR   EnsemblBacteria; ABC24335; ABC24335; Rru_A3541.
DR   KEGG; rru:Rru_A3541; -.
DR   PATRIC; fig|269796.9.peg.3658; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q2RNG0; -.
DR   Proteomes; UP000001929; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..929
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335217"
FT   REGION          22..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         678..685
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   929 AA;  98820 MW;  F934132105EA8BC0 CRC64;
     MLFFADRSPF VRPLSGYAPV TPAAPRSTGS AAAPPPSPAV LDDRSGTEGD VTPMMAQYLA
     VKAAHPDCLL FYRMGDFYEM FFEDAVKAAE TLDIALTKRG RHAGADIPMC GVPIHSHEGY
     LSRLIRAGIK VAICEQMEDP AEARRQRGYK AVVRRDVIRV VTAGTLTEDE LLDARAHNYL
     AAVVRLRDAV GMAWVDVSTG DLVAQPLAEA DIGPALARLA PGEVLMPEKL AGDPALREIL
     APLAGRISPL PASRFDSENA RKRVEGLFGV KALDGFGGFG RAEVAAIGAL IDYVELTQVG
     RLPRLSPPRR LSLGAILEID GATRRNLELT ETLGGGRKGS LLARIDCTVT GAGARLLAER
     LAAPLTDPAQ IGARLDGVGF LVSAERVRGD LRDTLRGCPD IARALSRLSL GRGGPRDLAA
     IGEALSRIPA LRVLVVGAGL GEPPTELTAA LIDLGSHEGL VDLLGRALDA DLPLLARDGG
     FIRPGYDAGL DELRALRDEG RRLIAGLQAR YASETAIPAL KIKHNNVLGY FIEVAAGRAD
     KLMAAGGPFL HRQTLASQVR FTTVELSELE DKIRGAADKA LALEQALFAT LCAEVLGCAA
     DIARAANGLA CLDVAAALAD LAARERYARP VVDNSTAFRI HKGRHPVVEA ALADQAGPAF
     VANDCDLAPD QRLWLLTGPN MAGKSTFLRQ NALIAVLAQM GSFVPAESAE IGVIDRLFSR
     VGAADDLARG RSTFMVEMVE TAAILNQATE RSLVILDEIG RGTATYDGLS IAWATVESLH
     DATRCRALFA THYHELTALA SRLDRLSCHT LRIKEWKDQV VFLHEVGPGA ADRSYGIHVA
     KLAGLPAAVI ARAEQVLAIL EKGDASSAAT RLADDLPLFA AARPRAGLPT PPPGPHPLAE
     ALNAINPDEM TPREALDALY RLKAVMKRE