ID   MUTS_RICAH              Reviewed;         886 AA.
AC   A8GMX2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A1C_02210;
OS   Rickettsia akari (strain Hartford).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=293614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hartford;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia akari.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000847; ABV74747.1; -; Genomic_DNA.
DR   RefSeq; WP_012149381.1; NC_009881.1.
DR   AlphaFoldDB; A8GMX2; -.
DR   SMR; A8GMX2; -.
DR   STRING; 293614.A1C_02210; -.
DR   EnsemblBacteria; ABV74747; ABV74747; A1C_02210.
DR   KEGG; rak:A1C_02210; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006830; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..886
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008085"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   886 AA;  100001 MW;  4735D2D468447EB5 CRC64;
     MNIQEFKQKY NYDVATKMMQ QYLDIKFAHL DCLLLFRMGD FYEMFYDDAI LASNVLGIAL
     TKRGKNGEEE IAMCGVPYHA LEHYLTKLIE ANYKVAICDQ LETPEDAKNR GGYKAVVTRD
     VTRIITPGTI IEENLIASAE PNYLASLVIP QNKETASICY VDLSTSEIFV VNVPEAEILN
     ELARLKPREI LVSENLRSSN LADSIFKQLN FRITYQVDSC FAINKCKKII LDFYKMKDIK
     GIGEISSSQI CVIGSILEYL SLTQKQNIPH LPIPRIINFH SYMTIDFSTR HNLAIVINSQ
     GSSNGSLLNT INHTVTKQGG RLLYNFLSSP LTNIAKINHR LNITEFFYSN LEIVQRIREL
     LKKTSDIERC LTRITMNRSS GCDLLSIKYT LEAATIIKGV FFDAYGFNLP DFIEKIIKPL
     AGDAELYHLI DESIRADVPN NLNDGGIIKH EYHPKVAQLH DLINNRKLHI EKLKDQYRKE
     TGIDSLKISH NNVIGLFIDI TAKNVNKILD PKFIHRQTTV NNVRYTTTEL QKLESELVNA
     KTLVISLEKA LYADICSQVI KKAAYLRMLA SSLSVLDVFC NFAYIADEYD YVKPELTDDL
     SFDIVKGRHP VVEKVLQRES KSFVYNDCHL SELKRIWLIT GPNMAGKSTF LRQNAIIAII
     AQIGSFVPAK SAKIGVVDKI FSRIGAADDL IKGQSTFMAE MLETSAILAQ STKNSLIILD
     EVGRGTSTYD GVSIAWSVLE YIHDKLKCRC LFATHYHELT VMNNFLPALQ NYTIAIEESG
     KDILFLHNII SGAADRSYGI HVAALAGLPA SVINRAEQIL LKFEKTSTGK GKNILSTESN
     NLRLFNLEHN QTTIRSKLEE QFRTIDPDQL SPKAALELIY ELKKLA