ID   MUTS_RICB8              Reviewed;         888 AA.
AC   A8GX86;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A1I_05820;
OS   Rickettsia bellii (strain OSU 85-389).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=391896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OSU 85-389;
RA   Madan A., Lee H., Madan A., Yoon J.-G., Ryu G.-Y., Dasch G., Ereemeva M.;
RT   "Complete genome sequencing of Rickettsia bellii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000849; ABV79486.1; -; Genomic_DNA.
DR   RefSeq; WP_012152067.1; NC_009883.1.
DR   AlphaFoldDB; A8GX86; -.
DR   SMR; A8GX86; -.
DR   KEGG; rbo:A1I_05820; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..888
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008086"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   888 AA;  100174 MW;  E330270C086C9204 CRC64;
     MNFQEFKHKY GYDAATKMMQ QYLDIKFAHL DCLLLFRMGD FYEMFYEDAV LASGVLGIAL
     TKRGKNGDEE VPMCGVPYHA LENYLTKLIE ENYKVAICDQ LETPEEAKNR GGYKAVVNRN
     VTRIITPGTV IEENLITTAE PNYLASLVVP KNKDTAALCY ADLSTSTIFV VNVPELEILN
     ELARLKPREI LLSEHLRSSD LASNISKQLN FRITYQVDSF FAVNKCEKII LDFYKMKDIK
     GVGEISNSQI CAIGSILEYL TLTQKENIPN LPKPKIIDFH SYMTIDFSTR RNLEIVTNSC
     GGNKGSLLST LNHTVTKQGG RLLYNFLSSP LTDTHKINQR LNITEFFHSN LDITAKVREL
     LKKTSDIERC LTRITMNRGS GRDLLSIKYT LETANSIKEI FFDNYGFELP SFIEKIVKPL
     IRNDELYNLI EESICEDAPN NLNDGGVIKH SYHPKVLQLH DLINNGKLHI EKLKDQYKKE
     TGIDSLKISH NNVIGLFIDI TAKNANKIND PKFIHRQTTV NSVRYTTAEL QKLESDLVNA
     KTLVVSLEKE LYEDICKRVT KQSDYLRILA SSLSGIDVFC NFAYIASEND YTRPEFTDDL
     SFDIVKGRHP VVEEALNKER KSFVHNDCHL SEAERIWLIT GPNMAGKSTF MRQNAIIAII
     AQIGSFVPAK SARIGMVDKI FSRIGAADDL IKGQSTFMAE MLETSAILAQ STKNSLIILD
     EVGRGTSTYD GVSIAWSVLE YIHDKLKCRC LFATHYHELT IMDNFLPAMQ NYTIAIEESG
     KDILFLHNII AGAADRSYGI HVAALAGLPA SVINRAEQIL LKFEKNAAGK GKNILSTESN
     NLSLFAIESP KLQNSKLEEK FKTIDPDKLS PKEALELLYQ LKSNFIKQ