ID   MUTS_RICCK              Reviewed;         891 AA.
AC   A8EZG1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A1E_04085;
OS   Rickettsia canadensis (strain McKiel).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=293613;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=McKiel;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia canadensis.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000409; ABV73744.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8EZG1; -.
DR   SMR; A8EZG1; -.
DR   STRING; 293613.A1E_04085; -.
DR   EnsemblBacteria; ABV73744; ABV73744; A1E_04085.
DR   KEGG; rcm:A1E_04085; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000007056; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008087"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  100931 MW;  00CCA343B177B6DA CRC64;
     MILLNMNLQE FKQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYEMF YEDATIASKV
     LGIALTKRGK NGEEEIPMCG IPYHALENYL TKLIKENHKI AICDQLETPE EAKNKGGYKA
     VVSRDVTRII TPGTIIEENF IASDEPNYLA SLVIPQNKET ASLCYVDLST SEIFVVNVPE
     AEILNELARL KPREILLSEN LRSSNLADNI FKQLNFRITY QVDSFFAVNK CEKIILDFYK
     MKDIKGIGEI SSGQICTIGS ILEYLSLTQK QNIPHLPIPR IINFHSYMAI DVATRRNLEI
     VTNSQGGSKG SVLSTINHTV TKQGGRLLYN FLSSPLTDIT KINQRLNITD FFYSNPAIVS
     KIREYLKRIS DIERCLTRIT MNRSSGHDLL SIKYTLETAT IIKGVFFDVY GVNLPDFIEK
     IIKPLTGNEE LYNLIEATIR EDAPHNLNEG GIIKHEYHPK VAQLHDLINN GKLHIEKLRD
     QYRKETGIDS LKICHNNVIG LFIDITAKNA NKITDPKFIH RQTTVNSVRY TTNELQKLES
     NLVNAKTLVI SLEKALYADI CRQVIVKSSY LRMLAISLSR LDVFCNFAYV ADEYDYVKPE
     FTNDLSFNIV KGRHPVVEKA LQRESKSFVY NDCRLSEFER IWLITGPNMA GKSTFLRQNA
     IIAIMAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS TFMAEMLETS AILAQSTKNS
     LIILDEVGRG TSTYDGVSIA WSVLEYIHDK LKCRCLFATH YHELTFMSNF LPALQNYTIA
     IEELGKDILF LHNIISGAAD RSYGIHVAAL AGLPASVINR AEQILLKFEK TSTIKGKNIL
     STESNNFSLF NLKPNKTTIS NKLYAKFRTI DPDKLSPKEA LELIYELKKM V