ID   MUTS_RICCN              Reviewed;         890 AA.
AC   Q92IL9;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RC0401;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE006914; AAL02939.1; -; Genomic_DNA.
DR   PIR; A97750; A97750.
DR   AlphaFoldDB; Q92IL9; -.
DR   SMR; Q92IL9; -.
DR   EnsemblBacteria; AAL02939; AAL02939; RC0401.
DR   KEGG; rco:RC0401; -.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115129"
FT   BINDING         645..652
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  100377 MW;  5016F26921D16792 CRC64;
     MLLNMNLQEL KQKYNYDVAT KMMQQYLDIK FAHLDCLLLF RMGDFYEMFY EDAILASNVL
     GIALTKRGKN GEEEIAMCGV PYHALENYLT KLIEANYKVA ICDQLETPEE AKNRGGYKAV
     VTRDVTRIIT PGTIIEENLI ASAEPNYLAS LVIPKNKETA SLCYVDLSTS EIVVVNVPET
     EILNELARLK PREILLSENL RSSNLADSIF KQLNFRITYQ VDSFFAINKC EKIILDFYKM
     KDIKGIGEIS SSQICAIGSV LEYLSLTQKQ NIPHLPIPRI IKFHSYMTID FSTRRNLEIV
     TNSQGGSQGS LLSTLNHTVT KQGGRLLYNF LSSPLTNIAK INHRLNITEF FYSNLEIVKK
     IRELLKKTSD IERCLTRITM NRSSGRDLLS IKYTLETATI IKGVFFDAYG FNLPDFIEKI
     IKPLSGDAEL YNLIDETIRE DAPNNLNDGG IIKHEYHPKV AQLHDLINNG KLYIEKLKDQ
     YRKETGIDSL KISHNNVIGL FIDITAKNVN KILDPKFIHR QTTVNHVRYT TAELQKLESE
     LVNAKTLVIS LEKELYADIC SQVIEKASYL RMLASSLSGL DVFCNFAYIA DEYDYVKPEF
     TDDLSFDIVK GRHPVVEKAL QRESKSFVYN DCHLSELERI WLITGPNMAG KSTFLRQNAI
     IAIIAQIGSF VPAKSAKIGV VDKIFSRIGA ADDLIKGQST FMAEMLETSA ILAQSTKNSL
     IILDEVGRGT STYDGVSIAW SVLEYIHDKL KCRCLFATHY HELTVMSNFL PALQNYTIAI
     EESGKDILFL HNIISGAADR SYGLHVAALA GLPASVINRA EQILLKFEKT STGKGKNILS
     TESNNLSLFY LEPNKTTISS KLDKKFSTID PDKLSPKEAL ELIYELKKLV