ID   MUTS_RICFE              Reviewed;         886 AA.
AC   Q4UM86;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RF_0483;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000053; AAY61334.1; -; Genomic_DNA.
DR   RefSeq; WP_011270815.1; NC_007109.1.
DR   AlphaFoldDB; Q4UM86; -.
DR   SMR; Q4UM86; -.
DR   STRING; 315456.RF_0483; -.
DR   EnsemblBacteria; AAY61334; AAY61334; RF_0483.
DR   KEGG; rfe:RF_0483; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..886
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224399"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   886 AA;  100023 MW;  6FF246F8D7127BEF CRC64;
     MNLQEFKQKY NYDVATKMMQ QYLDIKFAHL DCLLLFRMGD FYEMFYEDAI LASNVLGIAL
     TKRGKNGEEE IAMCGVPYHA LENYLTKLIE ENYKVAICDQ LETPEEAKNR GGYKAVVTRD
     VTRIITPGTI IEENLIASAE PNYLASLVIT KNKETASLCY VDLSTSEIFV VNVPEAEILN
     ELARLKPREI LLSENLRSSN LADSIFKQLN FRITYQVDSF FAINKCEKII LDFYKMKDIK
     GIGEISSSQI CAIGSILEYL SLTQKQNIPH LPIPRIINFH SYMTIDFATR RNLEIVTNSQ
     GTLKGSLLNT LNHTVTKQGG RLLYNFLSSP LTNIAKINHR LNITEFFYSN LEIVKRIREL
     LKKTSDIERC LTRITMNRSS GRDLLSIKYT LEAATIIKGV FFDAYGFNLP DFIEKIIKPL
     SGDAELYNLI DESIREDAPN NLNDGGIIKH EYHPKVAQLH DLINNGKLHI EKLKDQYCKE
     TGIDSLKISH NNVIGLFIDI TAKNVNKILD PKFIHRQTTV NSVRYTTTEL QKLESELANA
     KTLVISLEKE LYADICNQVI EKASYLRMLA SSLSGLDVFC NFAYIADEYD YVKPEFTDDL
     SFDIVKGRHP VVEKALKRES KSFVYNDCHL SEFERIWLIT GPNMAGKSTF LRQNAIIAII
     AQIGSFVPAK SAKIGVVDKI FSRIGAADDL IRGQSTFMAE MLETSAILAQ STKNSLIILD
     EVGRGTSTYD GVSIAWSVLE YIHDKLKCRC LFATHYHELT VMSNFLPALQ NYTIAIEESG
     KDILFLHNII SGAADRSYGI HVAALAGLPA SVINRAEQIL LKFEKTSTGK GKNILSTESN
     NLSLFNLEPN KTTISSKLDE QFRTIAPDKL SPKEALELIY ELKKLV