ID   MUTS_RICM5              Reviewed;         891 AA.
AC   A8F164;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RMA_0410;
OS   Rickettsia massiliae (strain Mtu5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=416276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mtu5;
RX   PubMed=17916642; DOI=10.1101/gr.6742107;
RA   Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.;
RT   "Lateral gene transfer between obligate intracellular bacteria: evidence
RT   from the Rickettsia massiliae genome.";
RL   Genome Res. 17:1657-1664(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000683; ABV84650.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8F164; -.
DR   SMR; A8F164; -.
DR   EnsemblBacteria; ABV84650; ABV84650; RMA_0410.
DR   KEGG; rms:RMA_0410; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001311; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335218"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  100399 MW;  0C3A06564FA2E525 CRC64;
     MMLLNMNLQE LKQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYEMF YEDAILASNV
     LGIALTKRGK NGEEEIAMCG VPYHALENYL TKLIEENYKV AICDQLETPE EAKNRGGYKA
     VVTRDVTRII TPGTIIEENL IASAEPNYLA SLVIPKNKET ASLCYVDLST SEIVVVNVPE
     TEILNELARL KPREILLSEN LRSSNLADSI FKQLNFRITY QVDSFFAINK CEKIILDFYK
     MKDIKGIGEI SSSQICAIGS VLEYLSLTQK QNIPHLPIPR IINFHSYMTI DFSTRRNLEI
     VTNSQGGSQG SLLSTLNHTV TKQGGRLLYN FLSSPLTNIA KINHRLNITE FFYSNLEIVK
     KIRELLKKTS DIERCLTRIT MNRSSGRDLL SIKYTLETAT IIKGVFCDAY GVNLPDFIEK
     IIKPLSGDAE LYNLIDETIR EDAPNNLNDG GIIKHEYHPK VAQLHDLINN GKLHIDKLKD
     QYRKETGIDS LKISHNNVIG LFIDITAKNV NKILDPKFIH RQTTVNHVRY TTAELQKLES
     ELVNAKTLVI SLEKALYADI CSQVIEKASY LRMLASSLNG LDVFCNFAYI ADEYDYVKPE
     FTDALSFDIV KGRHPVVEKA LQRESKSFVY NDCHLSELER IWLITGPNMA GKSTFLRQNA
     IIAIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS TFMAEMLETS AILAQSTKNS
     LIILDEVGRG TSTYDGVSIA WSVLEYIHDK LKCRCLFATH YHELTVMSNF LPALQNYTIA
     IEESGKDILF LHNIISGAAD RSYGLHVAAL AGLPASVINR AKQILLKFEK TSTGKGKNIL
     SMESNNLSLF NLEPNKTTIS SKLDEKFSTI DPDKLSPKEA LELIYELKKW V