ID   MUTS_RICPR              Reviewed;         891 AA.
AC   Q9ZDM9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=RP298;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235271; CAA14759.1; -; Genomic_DNA.
DR   PIR; E71685; E71685.
DR   RefSeq; NP_220682.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDM9; -.
DR   SMR; Q9ZDM9; -.
DR   STRING; 272947.RP298; -.
DR   EnsemblBacteria; CAA14759; CAA14759; CAA14759.
DR   KEGG; rpr:RP298; -.
DR   PATRIC; fig|272947.5.peg.307; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115130"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   891 AA;  101474 MW;  7CD9C09E955FC2FE CRC64;
     MTLCNMNLHE FRQKYNYNVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF YEDAILASNI
     LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLIEENYKV AICDQLETPE EAKKRDGYKA
     VVTRDVTRII TPGTIIEENL ISVTEPNYLT SLVIPKNKKT ASICCVDLST SKIFVINVPE
     TEILNELARL KSREILLSEN LKSSNISDSI LKQFNCRITY QVDSFFAINK CEKIILDFYK
     IRDIKGIGEI SNSQICAIGS ILEYLSLTQK QNIPHLPIPK IINFHNYMTI DFSTRRNLEI
     VTNLQGNLYG SVLNTLNHTV TTQGGRLLYH FLSSPLTNIA KINHRLNITE FFYSNLGIVT
     RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK TIKGLFSESY GLNLPHFIEK
     IIKPLSGDAE LYNLIHMSIR EDAPNNLNDG GIIKYEFHPK IAQLNDLINN KKLHVEKLKD
     QYRKETRIES LKISHNNVLG FFIDITPKNV NKILDPKFIH RQTTINSVRY TTYELQNLEN
     ELVNAQTLVI RLEKELYTDI CRKVIEKSSY LKILANSLSG LDVFCNFAYI ADEYDYTKPE
     FTNDLSFDIV KGRHPVVEAA LRKTSKSFVY NDCHLSEAER IWLITGPNMA GKSTYLRQNA
     IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS TFMAEMLETS AILAQSTKNS
     LIILDEVGRG TSTYDGVSIA WSVLEYIHDK LQCRCLFATH YHELTVMKNF LPALQNYTIA
     IEESGKDILF LHNIILGASN KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKEKNIL
     SNASNNLSLF NFEHEKPISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V