ID   MUTS_RICRO              Reviewed;         890 AA.
AC   B0BWY8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RrIowa_0482;
OS   Rickettsia rickettsii (strain Iowa).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=452659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa;
RX   PubMed=18025092; DOI=10.1128/iai.00952-07;
RA   Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F.,
RA   Hackstadt T.;
RT   "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and
RT   avirulent Rickettsia rickettsii Iowa.";
RL   Infect. Immun. 76:542-550(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000766; ABY72364.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0BWY8; -.
DR   SMR; B0BWY8; -.
DR   STRING; 452659.RrIowa_0482; -.
DR   EnsemblBacteria; ABY72364; ABY72364; RrIowa_0482.
DR   KEGG; rrj:RrIowa_0482; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000796; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075559"
FT   BINDING         645..652
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  100608 MW;  80B59BE851287580 CRC64;
     MLLNMNLQEL KQKYNYDVAT KMMQQYLDIK FAHLDCLLLF RMGDFYEMFY EDAILASNVL
     GIALTKRGKN GEEEIAMCGV PYHALENYLT KLIEENYKVA ICDQLETPEE AKNRGGYKAV
     VTRDVTRIIT PGTIIEENLI ASAEPNYLAS LVIPKNKETA SLCYVDLSTS EIVVVNVPET
     EILNELARLK PREILLSENL RSSNLADSIF KQLNFRITYQ VDSFFAINKC KKIILDFYKM
     KDIKGIGEIS SSQICAIGSV LEYLSLTQKQ NIPHLPIPRI INFHSYMTID FSTRRNLEIV
     TNSQGDSQGS LLSTLNHTVT KQGGRLLYNF LSSPLTNIAK INHRLNITEF FYSNLEIVKK
     IRELLKKTSD IERCLTRITM NRSSGRDLLS IKYTLETATI IKEVFFDAYG FNLPDFIEKI
     IKPLSGDAEL YNLIDETIRE DAPNNLNDGG IIKHEYHPKV AQLHDLINNG KLYIEKLKDQ
     YRKETGIDSL KISHNNVIGL FIDITAKNVN KILDPKFIHR QTTVNHVRYT TAELQKLESE
     LVNAKTLVIS LEKELYADIC SQVIEKASYL RMLASSLSGL DVFCNFAYIA DEYDYVKPEF
     TDDLSFDIVK GRHPVVEKAL QRESKSFVYN DCHLSELERI WLITGPNMAG KSTFLRQNAI
     IAIIAQIGSF VPAKSAKIGV VDKIFSRIGA ADDLIKGQST FMAEMLETSA ILAQSTKNSL
     IILDEVGRGT STYDGVSIAW SVLEYIHDKL KCRCLFATHY HELTVMSNFL PALQNYTIAI
     EESGKDILFL HNIISGAADR SYGLHVAALA GLPESVINRA EQILLKFEKT STGKGKNILS
     TESNNLSLFY LEPNKTTISS KLDKKFSTID PDKLSPKEAL ELIYELKKLV