ID   MUTS_RICRS              Reviewed;         886 AA.
AC   A8GRI6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A1G_02290;
OS   Rickettsia rickettsii (strain Sheila Smith).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=392021;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheila Smith;
RA   Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Dasch G., Eremeeva M.;
RT   "Complete genome sequence of Rickettsia rickettsii.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000848; ABV76011.1; -; Genomic_DNA.
DR   RefSeq; WP_012150610.1; NC_009882.1.
DR   AlphaFoldDB; A8GRI6; -.
DR   SMR; A8GRI6; -.
DR   EnsemblBacteria; ABV76011; ABV76011; A1G_02290.
DR   GeneID; 45538989; -.
DR   KEGG; rri:A1G_02290; -.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006832; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..886
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008088"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   886 AA;  100136 MW;  51AAD77B924D50F5 CRC64;
     MNLQELKQKY NYDVATKMMQ QYLDIKFAHL DCLLLFRMGD FYEMFYEDAI LASNVLGIAL
     TKRGKNGEEE IAMCGVPYHA LENYLTKLIE ENYKVAICDQ LETPEEAKNR GGYKAVVTRD
     VTRIITPGTI IEENLIASAE PNYLASLVIP KNKETASLCY VDLSTSEIVV VNVPETEILN
     ELARLKPREI LLSENLRSSN LADSIFKQLN FRITYQVDSF FAINKCKKII LDFYKMKDIK
     GIGEISSSQI CAIGSVLEYL SLTQKQNIPH LPIPRIINFH SYMTIDFSTR RNLEIVTNSQ
     GDSQGSLLST LNHTVTKQGG RLLYNFLSSP LTNIAKINHR LNITEFFYSN LEIVKKIREL
     LKKTSDIERC LTRITMNRSS GRDLLSIKYT LETATIIKEV FFDAYGFNLP DFIEKIIKPL
     SGDAELYNLI DETIREDAPN NLNDGGIIKH EYHPKVAQLH DLINNGKLYI EKLKDQYRKE
     TGIDSLKISH NNVIGLFIDI TAKNVNKILD PKFIHRQTTV NHVRYTTAEL QKLESELVNA
     KTLVISLEKE LYADICSQVI EKASYLRMLA SSLSGLDVFC NFAYIADEYD YVKPEFTDDL
     SFDIVKGRHP VVEKALQRES KSFVYNDCHL SELERIWLIT GPNMAGKSTF LRQNAIIAII
     AQIGSFVPAK SAKIGVVDKI FSRIGAADDL IKGQSTFMAE MLETSAILAQ STKNSLIILD
     EVGRGTSTYD GVSIAWSVLE YIHDKLKCRC LFATHYHELT VMSNFLPALQ NYTIAIEESG
     KDILFLHNII SGAADRSYGL HVAALAGLPE SVINRAEQIL LKFEKTSTGK GKNILSTESN
     NLSLFYLEPN KTTISSKLDK KFSTIDPDKL SPKEALELIY ELKKLV