ID   MUTS_RICTY              Reviewed;         891 AA.
AC   Q68X73;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RT0289;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017197; AAU03769.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q68X73; -.
DR   SMR; Q68X73; -.
DR   STRING; 257363.RT0289; -.
DR   EnsemblBacteria; AAU03769; AAU03769; RT0289.
DR   KEGG; rty:RT0289; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224400"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  100714 MW;  3F48D3A78952C6A3 CRC64;
     MTLCNMNLYE FRQKYNYDVA TKMMQQYLDI KFAHLDCLLL FRMGDFYELF YEDAILASNI
     LGIALTKRGK NCEEEIPMCG VPYHALEHYL TKLITENYKV AICDQLETPE EAKKRGGYKA
     VVTRDVTRII TPGTIIEENL ISAAEPNYLT SLVMTKNKKT ASICYVDLST SKIFIVNVPE
     TEILNELARL KSREILLSEN LKSSNLADSI LKQFNCRITY QVDSFFAINK CEKIILDFYK
     IRDIKGIGEI SSSQICAIGS ILEYLSLTQK QNIPNLPIPK IINFHSYMTI DFSTRRNLEI
     VTNIQGNLHG SVLNTLNHTV TKQGGRLLYH FLSSPLTNIA KINRRLNITE FFYSNLGIVT
     RIRELLKNTS DIERCLTRIT MNRSSGRDLL SIKYTLETAK IINGLFSESH SLNLPNFIGK
     IIKPLSGDAE LYNLIDMSIR EDAPNNLNDG GIIKHEFHPK VAQLNDLINN GKLHVEKLKD
     QYRKETGIDS LKISHNNVLG LFIDITAKNV NKILDPKFIH RQTTVNSVRY TTYELQNLEN
     ELVNAQTLVI SLEKELYTDI CRKVIEKSSY LRILANSLSG LDVFCNFAYI ADEYNYTKPE
     FTNDLSFDIV KGRHPVVEAA LLKTSKSFVY NDCHLSEAER ICLITGPNMA GKSTYLRQNA
     IITIIAQIGS FVPAKSAKIG VVDKIFSRIG AADDLIKGQS TFMAEMLETS AILAQSTKNS
     LIILDEVGRG TSTYDGVSIA WSVLEYIHDK LKCRCLFATH YHELTVMKNF LPALQNYTIA
     IEESGKDILF LHNIILGTSN KSYGLHVAAL AGLPTSVINR AAQILLKFEK ISISKGKNIV
     STASNNLSLF NFEPQKHISN SKLDEEFKTI DPDKISPKEA LELIYKFKKL V