MUTS_ROSCS
ID MUTS_ROSCS Reviewed; 1088 AA.
AC A7NPT5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Rcas_3531;
OS Roseiflexus castenholzii (strain DSM 13941 / HLO8).
OC Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Roseiflexineae;
OC Roseiflexaceae; Roseiflexus.
OX NCBI_TaxID=383372;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13941 / HLO8;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C.,
RA Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.;
RT "Complete sequence of Roseiflexus castenholzii DSM 13941.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000804; ABU59581.1; -; Genomic_DNA.
DR RefSeq; WP_012122004.1; NC_009767.1.
DR AlphaFoldDB; A7NPT5; -.
DR SMR; A7NPT5; -.
DR STRING; 383372.Rcas_3531; -.
DR PRIDE; A7NPT5; -.
DR EnsemblBacteria; ABU59581; ABU59581; Rcas_3531.
DR KEGG; rca:Rcas_3531; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_0; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000000263; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..1088
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335219"
FT REGION 498..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 816..823
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 1088 AA; 121193 MW; 20FCB6DB9A1B7149 CRC64;
MTPAERRAFE RQLQQEFPGL ELHAWYRQYR SLKAAHPDAI LLYRLGDFYE TFDDDAKLVA
DLLEVTLTYK EFASQKGRDQ KQRCPMAGIP YHAVEGYVAR LVGAGYRVAI AEQMTETPSS
RTDTRPRSIF AAGIEQTALI GGHKMVERKV VRIITPGTII ESGMLPAERN NYLAALIADH
GRIGLAYADL STGEFAAIEF SGERAAQQAQ GELARLNPAE ILVPDRADLR LPGLEPSSAR
LEQDLEFLTR EERERVLPGE RIARRVEREN HARWAHGHVT AWSEQRWDLR NARDTLLHQF
GVHSLAGFGL ADRPLAIRAA GAIVQYARET QQGTVANLRA IRVYTPGDAM VLDPQTQRNL
ELLEGNSGTT RGSLIGVLDQ TRTPMGARLL RRWISQPLCD LARLRARHDA VDHFVNDAIL
RASVRETLRR VGDMERVVNR IIQGSGVATP RDMARLRDAL RALPDLVAAL EDWTPPQEDV
DLSGMSALQE SAALAAAPLD GITPPDDDHT EQEPTTISLR AQREARRRVS ARLTGDDLFD
EEEEQENAGQ PAPLPTTETV RASGESARPS FEMPSLHGHG ESPTLDACAD ILAFLETAID
DDPPALLGAS NYLRAGDNGE LPRRVIRPGF EPEIDRVVAA SRDAQRWISE LEPKERERTG
IKSLRVDYNR VFGYYIEVPK TYADQVPKHY IRKQTLTTGE RYFTDELKRY EEIVEQAQQR
LIDLERRAFA RICETLAGAG VRLLRTARTI ATIDVFAALA EAAVRGRYVR PELYDDTRLR
IIGGRHPVVE QTLDETFIPN DIEMDTETRQ ICLITGPNMS GKSTVLRQVA LIALMAQIGS
FVPADAAEIG VVDRIFTRIG AQDDIATGRS TFMVEMTETA ALLAQSTHRS LIILDEVGRG
TSTYDGMAIA QAVIEYIHNE PRLGCRTLFA THYHELTDLE RTLPRLKNYH MAATEQDGRV
VFLHELRPGG ADRSYGIHVA ELAGIPQPVI RRATELLAEL ERRAPRSTPQ PAPERTEERP
AAGRPTARSH SAARGDPPRA PDGQLSLFDL TPGPVIEMLR RLDINQLTPL EALNKLYELQ
KLARIGGG
