ID   MUTS_ROSDO              Reviewed;         878 AA.
AC   Q16D05;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RD1_0423;
OS   Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp.
OS   (strain OCh 114)) (Roseobacter denitrificans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseobacter.
OX   NCBI_TaxID=375451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33942 / OCh 114;
RX   PubMed=17098896; DOI=10.1128/jb.01390-06;
RA   Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H.,
RA   Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K.,
RA   O'Huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T.,
RA   Touchman J.W.;
RT   "The complete genome sequence of Roseobacter denitrificans reveals a
RT   mixotrophic rather than photosynthetic metabolism.";
RL   J. Bacteriol. 189:683-690(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000362; ABG30138.1; -; Genomic_DNA.
DR   RefSeq; WP_011566760.1; NZ_FOOO01000001.1.
DR   AlphaFoldDB; Q16D05; -.
DR   SMR; Q16D05; -.
DR   STRING; 375451.RD1_0423; -.
DR   EnsemblBacteria; ABG30138; ABG30138; RD1_0423.
DR   KEGG; rde:RD1_0423; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000007029; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335221"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   878 AA;  95429 MW;  9F3F97595552DBEB CRC64;
     MTVTPMMAQY LDLKAEYADA LLFYRMGDFY EMFFEDAVAA AEALDIALTK RGKHDGADIP
     MCGVPVHSAE GYLLTLIRKR FRVAVCEQME SPAEAKKRGS KSVVKRDVVR LVTPGTLTEE
     TLLDARRNNY LTSFAQVRDA KALAWTDIST GAFHVMPLTA LKLGPELARL APSELICSES
     AENDLREVAE DFGIALTGLA RAAFDSTSAE QRICDLFGVE TLDSYGSFTR AEVAAMGGII
     QYLDITQKGK LPLLRPPQRE TENRTIQIDA ATRRNLELTQ ALSGGRAGSL LAVIDRTITA
     AGGRLMSARI ASPSRDLETI TNRLDAVSFA QDHHDLCGAL RDHLRKVPDL DRALSRLSLD
     RGGPRDMAAI RNGLTQSAIL FETLGSHELP PLLADALNDL SRHDNLIDRL DATLVAEPPL
     LARDGGFIAT GFDAELDEAR SLRDEGRSVI ARMQQEFAAL TGITSLKIKH NNVLGYFIET
     TATHAEKMLS PPMSETFIHR QTTANQVRFT TVELSELETK ILNAGGRALE IEKRLYETLK
     SDILACSARI AQTASALAEL DLTTALATLA TTDGWVRPKV DDSRAFAIEN GRHPVVENAL
     RQQSGDPFIA NDCDLSAEED AAQIYLLTGP NMAGKSTYLR QNAIIALLAQ MGSFVPASCA
     HIGLISQLFS RVGASDDLAR GRSTFMVEMV ETAAILNQAD DRALVILDEI GRGTATYDGL
     SIAWATLEHL HDVNKSRALF ATHYHEMTAL AGKLPGVENA TVTVKEWEGE VIFLHEVKMG
     AADRSYGVQV AQLAGLPPAV ISRARAVLDM LEKGEREGGA TQKTLIDDLP LFSVAPAPAP
     APAKTSDVEA RLAEIHPDEL TPKQALELLY QLKEAANP