ID   MUTS_ROSS1              Reviewed;        1085 AA.
AC   A5UZK7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RoseRS_3706;
OS   Roseiflexus sp. (strain RS-1).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Roseiflexineae;
OC   Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=357808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.;
RT   "Complete sequence of Roseiflexus sp. RS-1.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000686; ABQ92060.1; -; Genomic_DNA.
DR   RefSeq; WP_011958402.1; NC_009523.1.
DR   AlphaFoldDB; A5UZK7; -.
DR   SMR; A5UZK7; -.
DR   STRING; 357808.RoseRS_3706; -.
DR   PRIDE; A5UZK7; -.
DR   EnsemblBacteria; ABQ92060; ABQ92060; RoseRS_3706.
DR   KEGG; rrs:RoseRS_3706; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..1085
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335220"
FT   REGION          533..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          997..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        544..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         812..819
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   1085 AA;  120397 MW;  D6E2B6707D2866B1 CRC64;
     MTPAERRAFE RQLQQEFPGL ELHAWYRQYR SLKAAHPDAI LLYRLGDFYE TFDDDAKLVA
     DLLEVTLTYK EFASQKGRDQ KQRCPMAGIP YHAVEGYVAR LVGAGYRVAI AEQITETPSS
     RTDTRPRSIF AAGIEQTSLT GSNRMVERKV VRVITPGTII ESGMIPAERN NYLAALIADH
     GRIGLAYADL STGEFAAVEF SGERAAQQAQ GELTRLNAAE ILVPDRADLR LPGLEPSSAR
     LEQDLEFLTR EERELLLPGE RVARRVEREN NARWAHGRVT AWPERRWDLR NAHDTLLHQF
     GVRSLAGFGL EDRPLAIRAA GAIVQYARET QQGVVANLRS IRAYTPGDAM FLDPQTQRNL
     ELLEGASGTT RGSLIGVLDQ TRTPMGARLL RRWVSQPLCD LTRLHARHDA VERFVTDAIL
     RASVRETLRR VGDMERVVNR IIQGVGVATP RDMARLRDAL RALPELVAAL GDWTPPPGEI
     DLTGVRTLPP SAATDPVSLT ENGNERIEPN QTSAVSLRAQ REARRRVSAR YADEDLFGEE
     EQNAPPVGSS NHAVGTQPSA DDEASPVTAF VDDQATETLA LDPCADMLAF LETAIDDEPP
     ALLGASNYLR AGENGEPPRR VIRPGFEPEI DQVVAASRDA QRWISELEPK ERERTGIKSL
     RVDYNRVFGY YIEVPKTYAD QVPKHYIRKQ TLTTGERYFT DELKRYEEIV EQAQQRLIDL
     ERRAFARICD VVTGAGARLL RTARMIATID VFAALAEAAV RGRYVRPELY DDTRLRIVGG
     RHPVVEQTLD ETFVPNDIEM DTETRQICLI TGPNMSGKST VLRQVALIAL MAQIGSFVPA
     DAAEIGLVDR IFTRIGAQDD IATGRSTFMV EMTETAALLA QSTRRSLIIL DEVGRGTSTY
     DGMAIAQAVI EYIHNEPRLG CRTLFATHYH ELTDLERTLP RLKNYHMAAT EQDGRVVFLH
     ELRPGGADRS YGIHVAELAG IPQSVIRRAS ELLAELERRA PRSAPPTVPA RGDDRRSAGR
     ASSSGAGAAR GEQGRTLPDG QLSLFDLAPG PVIEMLRRID INQLTPLEAL NKLHELQKLA
     RAGGG