ID   MUTS_RUEPO              Reviewed;         877 AA.
AC   Q5LWH0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SPO0011;
OS   Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter
OS   pomeroyi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
RX   PubMed=15602564; DOI=10.1038/nature03170;
RA   Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA   Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.M.,
RA   Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E., Sheldon W.M.,
RA   Ye W., Miller T.R., Carlton J., Rasko D.A., Paulsen I.T., Ren Q.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Rosovitz M.J., Haft D.H., Selengut J., Ward N.;
RT   "Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine
RT   environment.";
RL   Nature 432:910-913(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3;
RX   PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA   Rivers A.R., Smith C.B., Moran M.A.;
RT   "An updated genome annotation for the model marine bacterium Ruegeria
RT   pomeroyi DSS-3.";
RL   Stand. Genomic Sci. 9:11-11(2014).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000031; AAV93342.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5LWH0; -.
DR   SMR; Q5LWH0; -.
DR   STRING; 246200.SPO0011; -.
DR   PRIDE; Q5LWH0; -.
DR   EnsemblBacteria; AAV93342; AAV93342; SPO0011.
DR   KEGG; sil:SPO0011; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001023; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..877
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224406"
FT   BINDING         630..637
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   877 AA;  95032 MW;  A558D9700D8722C7 CRC64;
     MTTVTPMMAQ YLEIKEAYAD ALLFYRMGDF YEMFFDDAVA AAEALDIALT KRGKHEGEDI
     PMCGVPVHAA EGYLLTLIRK GFRVAVCEQM ESPAEAKKRG SKSVVRRDVV RLVTPGTLTE
     DALLEARRHN FLVAYAEVRS GAALAWADIS TGDFHVMPVT RPRLSPELAR LAPSELLVVD
     EPVFQQLRPL ADDHRIPLTP LGKASFDSMA AEKRLCELYK VGSLEGFGTF ARAELSAMGA
     LIDYLDITQK GKLPLLQPPV QEAEDRVMQI DAATRRNLEL TRSLSGERGG SLLSVIDRTV
     TPGGARLLEQ RLGSPSRNLD VIHARLSALD FCIDHSTLAA DLRAALRKTP DLDRALSRLA
     LDRGGPRDLA AIRNGLGQAE AIAALCDGLE LPGLIAGACA DLNGFDELLG LLDTALVAEP
     PLLARDGGFI APGYDSDLDE ARELRDKGRG VIAGMQQKYA EHTGIASLKI KHNNVLGYFI
     ETTATHAAKM LNPPLSETYI HRQTTANQVR FTTVELSELE TRILNAGNHA LEIEKRLYSS
     LSGAVLEQAA RLNIAARGLA ELDLATALAD LARAENWCRP SVDPSRAFAI EGGRHPVVEH
     ALRRQGGDPF VANDCDLSAD KGAAIRLLTG PNMAGKSTYL RQNALITLLA QIGSYVPADS
     AHIGVVSQLF SRVGASDDLA RGRSTFMVEM VETAAILNQA DDHALVILDE IGRGTATYDG
     LSIAWATLEH LHATNRCRAL FATHYHELTA LAATLDGVEN LTVAVKEWEG EVIFLHEVRK
     GAADRSYGVQ VAQLAGLPPS VVARARVVLD QLEKSEREGG KQKALIDDLP LFSAAPPLPP
     PAPKTSPADA MLKEIHPDEL TPRQALEMLY KLKEAAR