ID   MUTS_RUEST              Reviewed;         879 AA.
AC   Q1GCK9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=TM1040_2875;
OS   Ruegeria sp. (strain TM1040) (Silicibacter sp.).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria; unclassified Ruegeria.
OX   NCBI_TaxID=292414;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM1040;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Silicibacter sp. TM1040.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000377; ABF65607.1; -; Genomic_DNA.
DR   RefSeq; WP_011540188.1; NC_008044.1.
DR   AlphaFoldDB; Q1GCK9; -.
DR   SMR; Q1GCK9; -.
DR   STRING; 292414.TM1040_2875; -.
DR   PRIDE; Q1GCK9; -.
DR   EnsemblBacteria; ABF65607; ABF65607; TM1040_2875.
DR   KEGG; sit:TM1040_2875; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000636; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..879
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335225"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   879 AA;  95738 MW;  E16E3EE0DD064BEB CRC64;
     MSVTPMMAQY LEIKAQYPDA LLFYRMGDFY EMFFEDAVNA AEALDIALTK RGKHEGEDIP
     MCGVPVHAAE GYLLTLIRKG FRVAVGEQLE SPAEAKKRGS KSVVKRDVVR LVTPGTLTED
     SLLEARRHNF LVAYSELRDQ AALAWADIST GAFHVMPVAR VRLSPELARL APSELIVADG
     PIFDATLPLA EEYKIPLTPL GKASFDSTAA EKRLCHLFNV SALDGFGTFN RAEISAMGAV
     VDYLEITQKG KLPLLQPPLQ ESEDRTVQID ASTRRNLELT RSLSGGRAGS LLSVVDRTVT
     PGGARLLEQR LSSPSRNLDV ISARLEALDT IVEDPIRCDT LRGLLRKTPD IDRALSRLAL
     DRGGPRDLAA IRNALSQGED IERALQDPDL PTLLRDAAHS LEGFQDLLSL LDAALIAEPP
     LLARDGGFIA AGYDRELDEA RTLRDEGRSV IAGLQKKYAE HTGISSLKIK HNNVLGYFIE
     TTSTHAAKMQ SAPMSDTYIH RQTTANQVRF TTVELSEIET KILNAGNLAL EIEKRLYQRL
     SGAILDSAAR LNQAARGFAE IDLVTALADL ARAENWTRPR VDTSRAFHVD GGRHPVVEQA
     LRHQGGDSFV ANDCDLSPQD GAAIWLLTGP NMAGKSTFLR QNALIAVLAQ MGSYVPAEAA
     HIGMISQLFS RVGASDDLAR GRSTFMVEMV ETAAILNQAD DRALVILDEI GRGTATYDGL
     SIAWATLEHL HEVNRSRALF ATHYHELTQL ATKLTGVENA TVSVKEWEGE VIFLHEVKKG
     AADRSYGVQV AQLAGLPASV VARARSVLDM LEKSSREGGG AGKVQIDDLP LFAAAPAPQP
     KPAQGPSPVE KLLEEIFPDD LTPREALETL YRLKDVSKG