ID   MUTS_RUMCH              Reviewed;         873 AA.
AC   B8I2Q5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ccel_1697;
OS   Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 /
OS   H10) (Clostridium cellulolyticum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminiclostridium.
OX   NCBI_TaxID=394503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35319 / DSM 5812 / JCM 6584 / H10;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Zhou J., Richardson P.;
RT   "Complete sequence of Clostridium cellulolyticum H10.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001348; ACL76048.1; -; Genomic_DNA.
DR   RefSeq; WP_015925163.1; NC_011898.1.
DR   AlphaFoldDB; B8I2Q5; -.
DR   SMR; B8I2Q5; -.
DR   STRING; 394503.Ccel_1697; -.
DR   EnsemblBacteria; ACL76048; ACL76048; Ccel_1697.
DR   KEGG; cce:Ccel_1697; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001349; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118678"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  98402 MW;  895A6EF21B377476 CRC64;
     MGTVTPMMQQ YLDIKEQYKD CILFFRLGDF YEMFFSDAEL ASRELEITLT GRDCGLEERA
     PMCGVPFHAA DNYIARLVSK GYKVAICEQV EDPALAKGIV KRDVVKVVTP GTVTDITMLD
     ERKNNYLMSV YKNGNFYGLA SVDITTGDFY ATRITWGNTR GKLLDEIAKY LPSEIIVNNE
     LNSDNELTSE IKQRFNTYVS TFEETSFEYG NSMDILANHF EKQTLNIQEY DIAVNASGAL
     LKYLESTQKV NLSHIQKFNS YALEEYMILD ASSRRNLELT ETMREKSKKG SLLWVLDKTM
     TSMGGRLLRK WIEQPLINHG DISLRLDAVE ELKNKFMVRV EARELLKRVY DIERLMGKVV
     LGSVNCRDLI ALKNSMCQIP YIKSLLNGFE AEYIKNCGEQ LDCLEDVCNL IEVSIIDEPP
     VTIKEGGIIK DGYNPEVDKL RMASIQGKDW IAALEASQRE KTGIKNLKVG FNRVFGYYIE
     VTKSYFSLVP EEYIRKQTLS NCERYITPEL KEIEDTILGA EEKIIQLEYS LFVEIKEKIA
     EQLSRIKSTA RALAEIDVLA SLAEVADREG YCKPEVSLSD KIEIIEGRHP VVEKMTDKSG
     FVPNDTVLDM EEDRLAIITG PNMAGKSTYM RQTALIVLMA QIGSFVPAAT AKIGLVDRIF
     TRVGASDDLA SGQSTFMVEM SEVANILINA TKRSLLVLDE IGRGTSTFDG LSIAWAVIEY
     IVNKEQLGCR TLFATHYHEL TELEGKLPGI KNYCITVKEK GEDVIFLRKI IRGGADGSYG
     IQVAKLAGVP QSVIDRAKEI LSNLDDADIN RSGKARRIKK QVDGQLDLFA QAAKASADAE
     ILEEIRKIDI SRLTPIDSMN ILYELQRKMN NRE