ID   MUTS_SACD2              Reviewed;         887 AA.
AC   Q21LB1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sde_1256;
OS   Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Saccharophagus.
OX   NCBI_TaxID=203122;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2-40 / ATCC 43961 / DSM 17024;
RX   PubMed=18516288; DOI=10.1371/journal.pgen.1000087;
RA   Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M.,
RA   Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H.,
RA   Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R.,
RA   Richardson P.M., Borovok I., Hutcheson S.;
RT   "Complete genome sequence of the complex carbohydrate-degrading marine
RT   bacterium, Saccharophagus degradans strain 2-40 T.";
RL   PLoS Genet. 4:E1000087-E1000087(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000282; ABD80518.1; -; Genomic_DNA.
DR   RefSeq; WP_011467738.1; NC_007912.1.
DR   AlphaFoldDB; Q21LB1; -.
DR   SMR; Q21LB1; -.
DR   STRING; 203122.Sde_1256; -.
DR   PRIDE; Q21LB1; -.
DR   EnsemblBacteria; ABD80518; ABD80518; Sde_1256.
DR   KEGG; sde:Sde_1256; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001947; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..887
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335222"
FT   REGION          828..853
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   887 AA;  97862 MW;  D4F5F2077529A209 CRC64;
     MNSTSTATPI ANENHTPMMQ QYLRIKAEHP NEIVFYRMGD FYELFFDDAK KAAKLLDVTL
     TARGKSNGEP IPMAGVPYHA AENYLAKLVR LGVSVAIVEQ VGDPATTKGP VERKVMRIVT
     PGTVSDEALL DETRDNLLVA ITLKDERYGI SSLDMGSGRF TVFEVADEEA LIGEIERLQP
     AELLAPELLT VPNIISLRAG YRRRPDWEFE YDTAQRLLTR HFGTQDLSGF GCEDFTAGIS
     AAGCLFAYAQ ETQKTTLSHV AKLVLDNPET KVTLDAATRR NLELDTNLAG TEDNTLFSVL
     NTTTTAMGGR LLRRWLHSPL RDIYILNQRQ SAIEALLDNY QFEPLRHTLK HISDLERILG
     RLALRSARPR DLSRLCASIA EFPAIQQHLN GIDSPLLKKL AKEIREFPDL VDLLSRALME
     NPPVVIREGG VIAEGFDEEL DELRAISTNA GDYLIKLEEQ ERAKTGLSTL KVGYNRVHGY
     YIEISKSQAS SAPTEYIRRQ TLKNAERFIT PELKTFEDKA LSAKSRALAR EKGLYDDLIE
     TLNEQLRELQ VAASGVAELD VLTTLAERSN LLNFCKPELY EGEGIFIEQG RHPVVEQVLD
     DPFVPNDLLL DTDQRMLIIT GPNMGGKSTY MRQTALIVLL AQIGCYVPAS ACKLGLVDRI
     FTRIGSSDDL AGGRSTFMVE MTETANILNN ATRNSLVLMD EIGRGTSTYD GLSLAWACVE
     HLANNLHAFT LFATHYFELT GLPKALAGVQ NVHLDATEHN DSIVFLHKIQ PGPASKSFGL
     QVAKLAGIPS NVIADAGGHL RRLEAQPTVD TPHQFPAPEP IALQEPVAEP EPNKPAAAAK
     TKPASPQPDL FASAAPSAVE IKLRSINPDN LTPRQALQAL YDLKDIS