ID   MUTS_SALAR              Reviewed;         860 AA.
AC   A9MF43;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SARI_00042;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000880; ABX19995.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9MF43; -.
DR   SMR; A9MF43; -.
DR   STRING; 41514.SARI_00042; -.
DR   PRIDE; A9MF43; -.
DR   EnsemblBacteria; ABX19995; ABX19995; SARI_00042.
DR   KEGG; ses:SARI_00042; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335223"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  95960 MW;  B7239C66E676904F CRC64;
     MSKINMNEDI DKDFSSHTPM MQQYLKLKAQ HPEILLFYRM GDFYELFYDD AKRASQLLDI
     SLTKRGASAG EPIPMAGIPH HAVENYLAKL VNQGESVAIC EQIGDPATSK GPVERKVVRI
     VTPGTISDEA LLQERQDNLL AAIWQDGKGY GYATLDISSG RFRLSEPADR ETMAAELQRT
     NPAELLYAED FAEMALIEGR RGLRRRPLWE FEIDTARQQL NLQFGTRDLV GFGVENASRG
     LCAAGCLLQY VKDTQRTSLP HIRSITMERQ QDSIIMDAAT RRNLEITQNL AGGIENTLAA
     VLDCTVTPMG SRMLKRWLHM PIRNTDILRE RQQTIGALQD TVSELQPVLR QVGDLERILA
     RLALRTARPR DLARMRHAFQ QLPELHAQLE TVDSAPVQAL RKKMGDFAEL RDLLERAIID
     APPVLVRDGG VIAPGYHQEL DEWRALADGA TDYLDRLEIR ERERTGLDTL KVGYNAVHGY
     YIQISRGQSH LAPINYVRRQ TLKNAERYII PELKEYEDKV LTSKGKALAL EKQLYDELFD
     LLLPHLADLQ QSASALAELD VLVNLAERAY TLNYTCPTFT DKPGIRIIEG RHPVVEQVLN
     EPFIANPLNL SPQRRMLIIT GPNMGGKSTY MRQTALIALL AWIGSYVPAQ NVEIGPIDRI
     FTRVGAADDL ASGRSTFMVE MTETANILHN ATENSLVLMD EIGRGTSTYD GLSLAWACAE
     NLANKIKALT LFATHYFELT QLPEKMEGVA NVHLDALEHG DTIAFMHSVQ DGAASKSYGL
     AVAALAGVPK EVIKRARQKL RELESISPNA AATQVDGTQM SLLAAPEETS PAVEALENLD
     PDSLTPRQAL EWIYRLKSLV