ID   MUTS_SALDC              Reviewed;         855 AA.
AC   B5FTQ5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SeD_A3218;
OS   Salmonella dublin (strain CT_02021853).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=439851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT_02021853;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001144; ACH74548.1; -; Genomic_DNA.
DR   RefSeq; WP_001005805.1; NC_011205.1.
DR   AlphaFoldDB; B5FTQ5; -.
DR   SMR; B5FTQ5; -.
DR   KEGG; sed:SeD_A3218; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008322; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093641"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95324 MW;  B2748109BD1AF7F3 CRC64;
     MNESFDKDFS NHTPMMQQYL KLKAQHPEIL LFYRMGDFYE LFYDDAKRAS QLLDISLTKR
     GASAGEPIPM AGIPHHAVEN YLAKLVNQGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
     ISDEALLQER QDNLLAAIWQ DGKGYGYATL DISSGRFRLS EPADRETMAA ELQRTNPAEL
     LYAEDFAEMA LIEGRRGLRR RPLWEFEIDT ARQQLNLQFG TRDLVGFGVE NASRGLCAAG
     CLLQYVKDTQ RTSLPHIRSI TMERQQDSII MDAATRRNLE ITQNLAGGVE NTLAAVLDCT
     VTPMGSRMLK RWLHMPVRNT DILRERQQTI GALQDTVSEL QPVLRQVGDL ERILARLALR
     TARPRDLARM RHAFQQLPEL HAQLETVDSA PVQALRKKMG DFAELRDLLE RAIIDAPPVL
     VRDGGVIAPG YHEELDEWRA LADGATDYLD CLEIRERERT GLDTLKVGYN AVHGYYIQIS
     RGQSHLAPIN YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKQLY DELFDLLLPH
     LADLQQSANA LAELDVLVNL AERAWTLNYT CPTFTDKPGI RITEGRHPVV EQVLNEPFIA
     NPLNLSPQRR MLIITGPNMG GKSTYMRQTA LIALLAYIGS YVPAQNVEIG PIDRIFTRVG
     AADDLASGRS TFMVEMTETA NILHNATENS LVLMDEIGRG TSTYDGLSLA WACAENLANK
     IKALTLFATH YFELTQLPEK MEGVANVHLD ALEHGDTIAF MHSVQDGAAS KSYGLAVAAL
     AGVPKEVIKR ARQKLRELES ISPNAAATQV DGTQMSLLAA PEEASPAVEA LENLDPDSLT
     PRQALEWIYR LKSLV