ID   MUTS_SALRD              Reviewed;         908 AA.
AC   Q2S254;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SRU_1606;
OS   Salinibacter ruber (strain DSM 13855 / M31).
OC   Bacteria; Bacteroidetes; Bacteroidetes Order II. Incertae sedis;
OC   Rhodothermaceae; Salinibacter.
OX   NCBI_TaxID=309807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13855 / CECT 5946 / M31;
RX   PubMed=16330755; DOI=10.1073/pnas.0509073102;
RA   Mongodin E.F., Nelson K.E., Daugherty S., DeBoy R.T., Wister J., Khouri H.,
RA   Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K.,
RA   Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L.,
RA   Legault B., Rodriguez-Valera F.;
RT   "The genome of Salinibacter ruber: convergence and gene exchange among
RT   hyperhalophilic bacteria and archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000159; ABC45289.1; -; Genomic_DNA.
DR   RefSeq; WP_011404353.1; NC_007677.1.
DR   RefSeq; YP_445727.1; NC_007677.1.
DR   AlphaFoldDB; Q2S254; -.
DR   SMR; Q2S254; -.
DR   STRING; 309807.SRU_1606; -.
DR   EnsemblBacteria; ABC45289; ABC45289; SRU_1606.
DR   KEGG; sru:SRU_1606; -.
DR   PATRIC; fig|309807.25.peg.1667; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008674; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..908
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008089"
FT   REGION          822..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..855
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         629..636
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   908 AA;  100733 MW;  31B9FB77AB90AF9A CRC64;
     MAQSSTQQRG RTPLMRQYYK IKERHPKAIL LFRMGDFYES FDDDAKTVSR LLGITLTERN
     NGDADDVPMA GFPHHALDSH LPKLIRSGLR VAICEQVEDA DDSSGKVVDR DVVEVVTPGV
     SFHDQLLNPK QSNFLAALHF GTGRDKDRIG FSFIDATTGE FSVTEAGLDQ LQDLIQTVAP
     SEVIVDKRKT ERLQQHLREV PFTVTEQEDW VFKYDFAYQT LLEHFETHSL KGFGVDDMDL
     GVVASGAALH YLGETQKGAL PHVRKIKRYS KDEHIALDPE TKRNLELVQS IQDDGHEGTL
     VSILDETETP MGGRRLRAWL VRPLRDVGRI RHRLDAVEAC VDDRTLRDDL REELNQMGDL
     ERLAGKVATG RAAPGDLIAI KHTLRRLPNV LGLLTDADSD ALGAIEDDLR SCPEMVDRIQ
     SALVDDPPAK ISEGGLIRDG YSEELDELRT IAQEGKDWVA NLETEESERT DIPSLKVGFN
     KVFGYYIEVT NTHADKVPED YIRKQTLVDS ERYVTPELKE MEEKILTAEE KIETLEQELF
     NELRSQIAQQ TGILQENAEL LAHLDCFAGL AEVAEQHDYT RPSVDDGLTI DIEEGRHPVV
     EQTLPPGDPF IPNDMALDPD DEQVLIITGP NMAGKSVALR QVGLIVLLAQ VGSFVPAEAA
     QIGVVDRIFT RVGASDNLAA GESTFLVEMN EAANILNNAT ARSLILFDEV GRGTSTFDGL
     SIAWAIVEYL HERPEVAART LFATHYHELN AMADRLERVH NYRIQVSEHE GEIVFLRKLI
     PGGADHSYGI EVAKMAGLPD AVIARAREVL QNLESQHLEV GADEADGAPS EDPPSEDPPS
     GDGVRAKKGE ADAVPDLEDS QANQMHLFGQ PDPAAEEIKE MLGEIDPNRI TPVEALMKLA
     EMKETLAD