ID   MUTS_SHEAM              Reviewed;         854 AA.
AC   A1S4E6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sama_1045;
OS   Shewanella amazonensis (strain ATCC BAA-1098 / SB2B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=326297;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1098 / SB2B;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Fredrickson J.,
RA   Richardson P.;
RT   "Complete sequence of Shewanella amazonensis SB2B.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000507; ABL99252.1; -; Genomic_DNA.
DR   RefSeq; WP_011759161.1; NC_008700.1.
DR   AlphaFoldDB; A1S4E6; -.
DR   SMR; A1S4E6; -.
DR   STRING; 326297.Sama_1045; -.
DR   PRIDE; A1S4E6; -.
DR   EnsemblBacteria; ABL99252; ABL99252; Sama_1045.
DR   KEGG; saz:Sama_1045; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000009175; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008090"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  95477 MW;  DFB172C4E5D7AD64 CRC64;
     MNSTDLLDLE KHTPMMRQYL TMKAAHPDML LFYRMGDFYE LFYDDAKRAS EMLSISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVQLGQ SVAICEQIGD PATAKGPVER KVVRVVTPGT
     LTDEALLQER QDNLLAAVYQ GKVGYGFATL DVASGRFVIA ELPSREALEA ELQRTSPAEL
     LYSEDFGDMG LINHIRGKRR RPEWEFDYDT CIKMLLEQFG TRDLRGFGIA DARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQGDSII LDAATRRNLE LTVSLSGSRE NTLASVLDNT
     VTAMGSRMLQ RWIHQPLRCH DTIRGRQQAV QELLETGLYE DLRAELKALG DIERILARLA
     LRSARPRDFA RLRDALGILP LIRERLQRCD ARHLKSLNIL LGDFPEEYEL LCRAIVDNPP
     VLIRDGGVIR EGYDSELDEW RKLSDGGIDY LEQMELREKE RTGIATLKVG FNRVHGYYIE
     VSRAQSALVP IAYQRRQTLK NTERYITPEL KEYEEKVLSS QGKALALEKQ LWEELFDLIL
     PKLQELQDFA LAASELDVLA NFADRADLFN YHCPELSDTT GILIEAGRHP VVERVSQSPF
     IPNPVELSNH RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GSFVPAERAL IGPVDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA NSLVLMDEIG RGTSTYDGMS LAWSAAEYLA
     QKLGAMTLFA THYFELTQLP EMLPGVHNVH LDAIEHDDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPANVI KAAKHKLLQL ESRDHGVDMS KQQALPLTMT PEPSAAELRL EAIDPNDLSP
     RQALELLFEL KRLL