ID   MUTS_SHEB8              Reviewed;         856 AA.
AC   A6WR19;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Shew185_3127;
OS   Shewanella baltica (strain OS185).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=402882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS185;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brettar I., Rodrigues J., Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome of Shewanella baltica OS185.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000753; ABS09258.1; -; Genomic_DNA.
DR   RefSeq; WP_012089807.1; NC_009665.1.
DR   AlphaFoldDB; A6WR19; -.
DR   SMR; A6WR19; -.
DR   KEGG; sbm:Shew185_3127; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008092"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95394 MW;  A856C082ECBE0AD0 CRC64;
     MNVIDTDDLE KHTPMMRQYL TMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQIGQ SVAICEQIGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAAVYQ GKIGFGYATL DVSSGRFVIA ELDTRESLEA ELQRTNPVEI
     LYSEDFGELG LLNGFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIA DARLSLQAAG
     CLMQYVKDTQ RTALPHINAI TRFNQTDSIV LDAATRRNLE LTQNLAGGRD NTLAAVLDNT
     ATPMGSRMLQ RWIHQPLRDP KHIKARQQAV TELLDTAAHE GLHEQLKALG DIERIMARLA
     LRTARPRDFA RLRQALGLLP ELQQSLSTLS APHTTQLRQH LGEFPAEQAL LERAIVDNPP
     MLIRDGGVIR EGYNSELDEW RGLSEGASDY LVQLEAREKE RTGINTLKVG YNRVHGYYIE
     VSRLQSSQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWEQLFDFIL
     PKLHELQDFA RAAAELDVLS NFAERAETLG YTCPELSQDI GVQIEAGRHP VVERVSQTPF
     IANPVTLHNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPADRAL IGPIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA SSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QQVGAMTLFA THYFELTQLP ELMAGVYNVH LDAIEHDDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPNKVI KAAKHKLQQL ESRDHQAEGT RTPIQSLLAL PEPVENPALT KLSSINPDNL
     TPKQALDLLY ELKRLS