ID   MUTS_SHEDO              Reviewed;         862 AA.
AC   Q12PY3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sden_1207;
OS   Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OS217 / ATCC BAA-1090 / DSM 15013;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Shewanella denitrificans OS217.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000302; ABE54493.1; -; Genomic_DNA.
DR   RefSeq; WP_011495652.1; NC_007954.1.
DR   AlphaFoldDB; Q12PY3; -.
DR   SMR; Q12PY3; -.
DR   STRING; 318161.Sden_1207; -.
DR   EnsemblBacteria; ABE54493; ABE54493; Sden_1207.
DR   KEGG; sdn:Sden_1207; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001982; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..862
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008093"
FT   REGION          799..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        803..824
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   862 AA;  95456 MW;  D8ADF2A87AFD0F73 CRC64;
     MTSIDSSELE KHTPMMRQYL TMKAAHPEML LFYRMGDFYE LFYEDAKLAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQIGQ SVAICEQVGD PATSKGPVER KVVRIVTPGT
     LTDEALLQEH QDNLLAAIYQ GKVGFGYATL DISSGRFVIA ELDTQEALEA ELQRTRPVEL
     LYSEDFSNLS LINHLKGIRR RPEWEFDFDT SVNLLLQQFG TKDLHGFGIS DARLSLQAAG
     CLMQYVKDTQ KTALPHINAI VRFNQADSII LDAATRRNLE LTQNLSGGRE HTLAWVLDNT
     ATPMGSRMLQ RWLHQPLRDN NIIASRHNAV AELIEANLFD ELHQQLKSLG DIERIMARLA
     LRSARPRDFA RLRQALSLLP ELQHTLGQCK TPLLTKLAQL IGEFPAEHEL LENAIVDSPP
     MLIRDGGVIR SGYHSELDEW RALSEGASDY LTELEAREKQ ATGISTLKVG YNRVHGYYIE
     VSRLQADKVP LSYQRRQTLK GTERYITPEL KVYEEKVLSS QGKALALEKQ LWDQLFDLIL
     PKLNELRDFA NAAAELDVIC CFAERAESLH YTQPQMVSKT GIQINAGRHP VVERVSSTAF
     IANPVNLDAK RHMLIVTGPN MGGKSTYMRQ VALISLMAHI GCFVPADSAV IGPIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATS QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     LQIKAMTLFA THYFELTQLP DLIPGANNVH LDAIEHDDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPSHVI QAAKHKLHQL ESRDNQASPA VASAPQQQSL SLSPAPMMGE KALNKLTTIN
     PDELSPKQAL DLLYELKKLA KS