ID   MUTS_SHEFN              Reviewed;         861 AA.
AC   Q086A1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sfri_1061;
OS   Shewanella frigidimarina (strain NCIMB 400).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318167;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 400;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H.,
RA   Newman D., Tiedje J.M., Zhou J., Romine M.F., Culley D.E., Serres M.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.;
RT   "Complete sequence of Shewanella frigidimarina NCIMB 400.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000447; ABI70914.1; -; Genomic_DNA.
DR   RefSeq; WP_011636535.1; NC_008345.1.
DR   AlphaFoldDB; Q086A1; -.
DR   SMR; Q086A1; -.
DR   STRING; 318167.Sfri_1061; -.
DR   EnsemblBacteria; ABI70914; ABI70914; Sfri_1061.
DR   KEGG; sfr:Sfri_1061; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000684; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008094"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  96521 MW;  9CD029A89570EA42 CRC64;
     MTVIDTSDLE KHTPMMRQYL GLKAAHPDML LFYRMGDFYE LFYDDAKRAS EMLGISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVNIGQ SVAICEQIGD PATSKGPVER QVVRIVTPGT
     LTDEALLQEK QDNLLAALYQ GKTGFGYATL DISSGRFVVA ELPTREALEA ELQRTNPAEL
     LYSEDFTDML LINNMKGIRR RPEWEFDYDT CINLLLNQFG TKDLHGFGIT DARLALQAAG
     CLMQYVKDTQ KMALPHINSI VRFNQSESII LDAATRRNLE LTQNLSGGRE NTLAWVLDNT
     ATPMGSRMLQ RWIHEPLRNR QTIQYRHSAV SELIEQDLYQ TLHEQLKSLG DIERIMARLA
     LRSARPRDFS RLKQALTLLP EIQQTLAICQ QPRLNTLVQL LGEFPEQHDL LERAIVDNPP
     MLIRDGGVIR TGYNNELDEW RKLSEGASDY LVELEAREKQ QTGINTLKVG YNRVHGYYIE
     VSRLQSDRVP LSYQRRQTLK GTERYITPEL KEYEEKVLSS QGKALALEKQ LWEQLFDLLL
     PKLQELQQFA TAAAELDILS NFAERAELFN YQCPQMSHDI GINIEAGRHP VVERVSQAAF
     IANPVALTPQ RQMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPADHAQ IGEIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA NSLVLMDEIG RGTSTYDGLA LAWSAAEYLA
     KNVSALTLFA THYFELTQLP ELLPSVINVH LDAIEHDDTI AFMHSVQEGA ASKSYGLQVA
     ALAGVPASVI KAAKHKLHQL ENRDMTLSQQ NPTQVSMNLL PPIPEPSLAL EKLAQINPDE
     LTPKQALDYL YELKRLSHTN T