ID   MUTS_SHEHH              Reviewed;         859 AA.
AC   B0TK13;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Shal_1231;
OS   Shewanella halifaxensis (strain HAW-EB4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=458817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella halifaxensis HAW-EB4.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000931; ABZ75800.1; -; Genomic_DNA.
DR   RefSeq; WP_012276342.1; NC_010334.1.
DR   AlphaFoldDB; B0TK13; -.
DR   SMR; B0TK13; -.
DR   STRING; 458817.Shal_1231; -.
DR   EnsemblBacteria; ABZ75800; ABZ75800; Shal_1231.
DR   KEGG; shl:Shal_1231; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001317; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075561"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95920 MW;  68CB996178041340 CRC64;
     MTAIDPQGLE KHTPMMRQYL TLKAQHPDML LFYRMGDFYE LFYEDAKRAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQIGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAALYQ GKTGYGYATL DVASGRFVIT ELANTEALEA ELQRTNPAEL
     LYSEDFSEMS LIAAINGTRR RPEWEFDYDT CHRLLLNQFG TKDLKGFGIE DARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQSDSIV LDAATRRNLE LTVNLQGGRE NTLASVLDNT
     VTPMGSRMLQ RWLHQPLRDH DIIRARQVSI EELLGNANYE ILSEDLKAIG DIERITTRIA
     LRNARPRDFA RLRQALALLP QLQQTLTQAA APHLKYLSQV IGEFPDELEL LSRAVVDNPP
     MLIRDGGVIR EGYNEELDQW RKLSEGATDY LHELEAREKQ QTGISTLKVG YNRVHGYYIE
     VSRRESDLVP LSYQRRQTLK NTERYIIPEL KEHEEKVLSS QGRALALEKQ LWEQLFDLIL
     PKLHELQDFA RASAELDVLC NFAERAESLN YHCPDLSTAP GIQIEAGRHP VVEQVSQSPF
     IANPVTLNNE RKMLIVTGPN MGGKSTYMRQ VALITLMAHI GCYVPAEHAV IGPVDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATP NSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     KHLQAMTLFA THYFELTQLP ELLSNVENVH LDAVEHGDSI VFMHAVQEGA ASRSYGLQVA
     ALAGVPNCVI SAAKHKLHQL ESRDHGKESC DAQQPLQQSI SFSAPTPSPA LEALAKLNPD
     ELTPRQALDY LYNLKKLAL