ID   MUTS_SHELP              Reviewed;         855 AA.
AC   A3QC86;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Shew_1214;
OS   Shewanella loihica (strain ATCC BAA-1088 / PV-4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=323850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1088 / PV-4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Serres G.,
RA   Fredrickson J., Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella loihica PV-4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000606; ABO23084.1; -; Genomic_DNA.
DR   RefSeq; WP_011865016.1; NC_009092.1.
DR   AlphaFoldDB; A3QC86; -.
DR   SMR; A3QC86; -.
DR   STRING; 323850.Shew_1214; -.
DR   EnsemblBacteria; ABO23084; ABO23084; Shew_1214.
DR   KEGG; slo:Shew_1214; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001558; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..855
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008095"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   855 AA;  95576 MW;  BC872C569313FDE9 CRC64;
     MNAVDTQYLE KHTPMMRQYL TLKAETPDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVQLRV SVAICEQIGD PATTKGPVER KIVRIVTPGT
     LTDEALLQER QDNLLAAVYH GKVGFGYATL DVSSGRFVVT ELASKEALEA ELQRTNPAEL
     LYSEDFSEPA LIASLSGKRR RPEWEFDYDT SYKLLLEQFG TKDLYGFGLG EVRLSLQAAG
     CLIQYVKDTQ RTALPHINAI TRFNQCDSIV LDAATRKNLE LTRNLQGGSD NTLASVLDNT
     ATPMGSRMLQ RWIHEPLRNH NIIRARHDAI DELLDNGYHE SLHEQLKALG DIERITARLA
     IRSARPRDFA RLRQALALLP EIQQQLADCN SPHLKALSSH LGDFPEEHAL LSRAIVDNPP
     MLIRDGGVIK EGYHNELDEW RKLSQGATDY LAELEAREKA ATGASTLKVG YNRVHGYYIE
     VSRRESDLVP MSYQRRQTLK NTERYIVAEL KEHEEKVLSS QGKALALEKQ LWEELFDLLM
     PRLHELQAFA RAAAELDVIT NFAERAEQLD YHRPELTAQS GIHIEAGRHP VVERVSQTPF
     IANPVSLNPA RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GSFVPAQKAA IGPVDRIFTR
     IGAADDLASG RSTFMVEMTE TANILHNATP ESLVLMDEIG RGTSTYDGLS LAWSAAEHLA
     QNLKSMTLFA THYFELTQLP DQMENVANVH LDAIEHDDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPAKVV QAAKHKLHHL ESRDREEELP ELRQAQLSMT MPETSKALDR LDTIDPDSLT
     PRQALDLLYE LKQLR