ID   MUTS_SHEON              Reviewed;         856 AA.
AC   Q8EBR9;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SO_3431;
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1;
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J.,
RA   Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J.,
RA   Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V.,
RA   Smith H.O., Venter J.C., Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE014299; AAN56428.1; -; Genomic_DNA.
DR   RefSeq; NP_718984.1; NC_004347.2.
DR   RefSeq; WP_011073287.1; NZ_CP053946.1.
DR   AlphaFoldDB; Q8EBR9; -.
DR   SMR; Q8EBR9; -.
DR   STRING; 211586.SO_3431; -.
DR   PaxDb; Q8EBR9; -.
DR   PRIDE; Q8EBR9; -.
DR   KEGG; son:SO_3431; -.
DR   PATRIC; fig|211586.12.peg.3326; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q8EBR9; -.
DR   BioCyc; SONE211586:G1GMP-3202-MON; -.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115133"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95456 MW;  71E3D8B6051A0D1C CRC64;
     MNPIDTDDLE KHTPMMRQYL SMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVQIGQ SVAICEQIGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAAVYQ GKVGFGYATL DVSSGRFVIA ELETKESLEA ELQRTNPVEI
     LYSEDFGALD LLHHFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIT DARLSLQAAG
     CLMQYVKDTQ RTALPHINAI TRFNQTDTIV LDAATRRNLE LTQNLSGGRD NTLAAVLDNT
     ATAMGSRMLQ RWIHQPLRDH ALILARQTAV NELLETAVHE SLHEQLKALG DIERIMARLA
     LRTARPRDFA RLRQALSLLP QLQLSLSQLS APHTVKLGQL LGEFPQEQQL LEHAIVDNPP
     MLIRDGGVIR EGYNAELDEW RGLSEGASDY LVQLEAREKE RTGIATLKVG YNRVHGYYIE
     VSRLQSNQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWDELFDLIL
     PKLHELQDFA RAAAELDVLS NFAERAETLG YTSPELSSEI GVKIEAGRHP VVERVSQTPF
     IANPVTLHNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPAERAT IGPIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QQVGAMTLFA THYFELTQLP ELMSGVYNVH LDAIEHEDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPARVI KAAKHKLHQL ESRDHQVEGT KTPIQTLLAL PEPVENPAVS KLKAINPDNL
     TPKQALDLLY ELKRLS