ID   MUTS_SHEPA              Reviewed;         859 AA.
AC   A8H1T4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Spea_1194;
OS   Shewanella pealeana (strain ATCC 700345 / ANG-SQ1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=398579;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700345 / ANG-SQ1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Zhao J.-S.Z., Manno D., Hawari J., Richardson P.;
RT   "Complete sequence of Shewanella pealeana ATCC 700345.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000851; ABV86521.1; -; Genomic_DNA.
DR   RefSeq; WP_012154448.1; NC_009901.1.
DR   AlphaFoldDB; A8H1T4; -.
DR   SMR; A8H1T4; -.
DR   STRING; 398579.Spea_1194; -.
DR   EnsemblBacteria; ABV86521; ABV86521; Spea_1194.
DR   KEGG; spl:Spea_1194; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002608; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075562"
FT   REGION          803..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        809..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95870 MW;  2395BE862AFD5056 CRC64;
     MTAIDPQSLE KHTPMMRQYL TLKAQHPDML LFYRMGDFYE LFYEDAKKAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQVGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAALYQ GKTGYGYATL DVASGRFVVT ELANTEALEA ELQRTNPAEL
     LYSEDFSQMS LIAGMNGTRR RPEWEFDYDT CQRMLLNQFG TKDLKGFGIE DARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQSDSIV LDAATRRNLE LTVNLQGGRE NTLASVLDNT
     VTPMGSRMLQ RWIHQPLRDH DIIRARQASI AELMMTGDFE TLSEDLKALG DVERITARIA
     LRNARPRDFA RLRQALTLLP QLQQTLSAAS APHLKYLSQV IGVFPEEVDL LSRAVVDNPP
     MLIRDGGVIR EGYNEELDQW RKLSEGATDY LHELEAREKE QTGISTLKVG YNRVHGYYIE
     VSRRESDLVP LSYQRRQTLK NTERYIIPEL KEHEEKVLSS QGRALALEKQ LWEQLFDLIL
     PKLHELQDFA QASAELDVLC NFAERAESLN YHCPELSSIS GIHIEAGRHP VVEQVSQSPF
     IANPVTLNAQ RKMLIVTGPN MGGKSTYMRQ VALITLMAHI GCYVPAEQAV IGPVDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATP NSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     KQLQAMTLFA THYFELTQLP EQLSNVENVH LDAVEHGDSI VFMHAVQEGA ASRSYGLQVA
     ALAGVPNCVI SAAKHKLHQL ESRDHDVQQN TEQQGTQQNM SFVPSAPSPA VEALQKLNPD
     ELTPRQALDY LYNLKKLAL