ID   MUTS_SHEPW              Reviewed;         860 AA.
AC   B8CJQ5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=swp_1365;
OS   Shewanella piezotolerans (strain WP3 / JCM 13877).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=225849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WP3 / JCM 13877;
RX   PubMed=18398463; DOI=10.1371/journal.pone.0001937;
RA   Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L.,
RA   Bartlett D.H., Yu J., Hu S., Xiao X.;
RT   "Environmental adaptation: genomic analysis of the piezotolerant and
RT   psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans
RT   WP3.";
RL   PLoS ONE 3:E1937-E1937(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000472; ACJ28152.1; -; Genomic_DNA.
DR   RefSeq; WP_020911530.1; NC_011566.1.
DR   AlphaFoldDB; B8CJQ5; -.
DR   SMR; B8CJQ5; -.
DR   STRING; 225849.swp_1365; -.
DR   EnsemblBacteria; ACJ28152; ACJ28152; swp_1365.
DR   KEGG; swp:swp_1365; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000753; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000117292"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  95624 MW;  5C363B87D94B728E CRC64;
     MTAIEPQNLE KHTPMMRQYL TLKAQHPDML LFYRMGDFYE LFYEDAKLAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQIGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAALYQ GKSGYGYATL DIASGRFVIT ELANTEALEA ELQRTNPAEL
     LYSEDFSQMS LIAGMNGTRR RPEWEFDFDT CQRLLLNQFG TKDLNGFGIE GARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQTDSIV LDAATRRNLE LTVNLQGGHT NTLASVLDST
     VTAMGSRMLQ RWLHQPLRDH QVIKARQSSI AELIATENYQ LLAEDLKALG DVERITARIA
     LRNARPRDFA RLRQALGLLP QLQQTLKASS EPHLQYLSQV IGEFPEELAL LSRAVVDNPP
     MLIRDGGVIR DGYDAELDEW RVLSAGATDY LTQLEAREKE QTGISTLKVG YNRVHGYYIE
     VSRRESDLVP LSYQRRQTLK NTERYIIAEL KEHEEKVLSS QGKALALEKQ LWEELFDLIL
     PKLHELQEFA TAAAELDVLC NFAECAETLN YACPELSDAS GIHVEAGRHP VVEQVSQSPF
     IANPVTLNSQ RKMLIVTGPN MGGKSTYMRQ IALITLMAHI GCYVPAEHAV IGPVDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATP NSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     NNLNAMTLFA THYFELTQLP EQIKNVENVH LDAVEHGDSI VFMHAVQEGP ASRSYGLQVA
     ALAGVPNSVI CAAKQKLHHL ESRDHALEQS KNGEMAVQQT ISFPTQPTSP VIEALEKLNP
     DELTPRQALD YLYNLKKMAR