ID   MUTS_SHESH              Reviewed;         859 AA.
AC   A8FST7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ssed_1299;
OS   Shewanella sediminis (strain HAW-EB3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=425104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HAW-EB3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella sediminis HAW-EB3.";
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000821; ABV35910.1; -; Genomic_DNA.
DR   RefSeq; WP_012141646.1; NC_009831.1.
DR   AlphaFoldDB; A8FST7; -.
DR   SMR; A8FST7; -.
DR   STRING; 425104.Ssed_1299; -.
DR   PRIDE; A8FST7; -.
DR   EnsemblBacteria; ABV35910; ABV35910; Ssed_1299.
DR   KEGG; sse:Ssed_1299; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002015; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075563"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  95579 MW;  4B5259AD1621EC33 CRC64;
     MNAIDTQNLE KHTPMMRQYL TLKAEHPEML LFYRMGDFYE LFYDDAKKAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQVGD PATSKGPVER KVVRLVTPGT
     LTDEALLQEK QDNLLAAVYH GKSGYGYATL DISSGRFVVA ELASTEALEA ELQRTNPAEL
     LYSEDFSEMG LISGFNGKRR RPEWEFDFDT SQKLLLDQFG TKDLRGFGLD NARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQSDSIV LDAATRRNLE LTVNLQGGHE NTLASVLDNT
     ATPMGSRMLQ RWIHEPLRNQ QQIESRQSAL TEILDTNLFE TLEPQLKALG DVERITARLA
     LRSARPRDFA RLKQAISLLP EIQQSLANCQ SAHLHHLARM LGEFPDELEL LERAIVDNPP
     MLIRDGGVLK EGYNAELDQW RALSQGATDY LSELEAREKE QTGISTLKVG YNRVHGYYIE
     VSRRESDLVP LSYQRRQTLK NTERYIIAEL KEHEEKVLSS QGKALALEKQ LWEQLFDQIL
     PKLHDLQLFA QGAAELDVIN NFAERAETLN YSCPTLSQKS GIHIEGGRHP VVEQVSQTPF
     IANPVTLNPA RKMLIVTGPN MGGKSTYMRQ VALITLMTHI GCYVPAQSAV IGPVDRIFTR
     IGAADDLASG RSTFMVEMTE TANILHNATT ESLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QKIEAMTLFA THYFELTQLP ELISNVENVH LDAIEHGDTI VFMHAVQEGA ASKSYGLQVA
     ALAGVPGKVI TAAKHKLHHL ESRDTNSAVD SMTTSNQQSM VFDEPVNSAL NDALDKIHPD
     ELSPRQALDI LYELKRLTS