ID   MUTS_SHESM              Reviewed;         861 AA.
AC   Q0HL63;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Shewmr4_1124;
OS   Shewanella sp. (strain MR-4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=60480;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA   Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella sp. MR-4.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000446; ABI38204.1; -; Genomic_DNA.
DR   RefSeq; WP_011621913.1; NC_008321.1.
DR   AlphaFoldDB; Q0HL63; -.
DR   SMR; Q0HL63; -.
DR   KEGG; she:Shewmr4_1124; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008098"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  96089 MW;  E3F18D30E7BC7692 CRC64;
     MNPIDTDDLE KHTPMMRQYL TMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVQIGQ SVAICEQIGD PATSKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAAVYQ GKVGFGYATL DVSSGRFVIA ELETKESLEA ELQRTNPVEI
     LYSEDFGAME LLHHFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIT DARLSLQAAG
     CLMQYVKDTQ RTALPHINAI TRFNQTDTIV LDAATRRNLE LTQNLSGGRD NTLAAVLDNT
     ATAMGSRMLQ RWIHQPLRDH AQIFARQTAV NELLETTAHE SLHEQLKALG DIERIMARLA
     LRTARPRDFA RLRQALNLLP KLQQSLAQLS APHTVKLGQL LGEFPEEQQL LERAIVDNPP
     MLIRDGGVIR EGYNAELDEW RGLSEGATDY LVQLEAREKE RTGIATLKVG YNRVHGYYIE
     VSRLQSQQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWDELFDLIL
     PKLHELQAFA RAAAELDVLS NFAERAETLG YTCPELSSEI GVKIEAGRHP VVERVSQTPF
     IANPVTLYNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPADRAI IGPIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QQVGAMTLFA THYFELTQLP ELMAGVYNVH LDAIEHEDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPARVI KAAKHKLHQL ESRDHQVEGV NVNGTRAPIQ TLLALPEPVE NPAVSKLKAI
     NPDNLTPKQA LDLLYELKRL S