MUTS_SHESR
ID MUTS_SHESR Reviewed; 861 AA.
AC Q0HXG1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Shewmr7_1195;
OS Shewanella sp. (strain MR-7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=60481;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MR-7;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Nealson K.,
RA Konstantinidis K., Klappenbach J., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 1 of Shewanella sp. MR-7.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000444; ABI42194.1; -; Genomic_DNA.
DR RefSeq; WP_011625572.1; NC_008322.1.
DR AlphaFoldDB; Q0HXG1; -.
DR SMR; Q0HXG1; -.
DR EnsemblBacteria; ABI42194; ABI42194; Shewmr7_1195.
DR KEGG; shm:Shewmr7_1195; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..861
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008099"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 861 AA; 96141 MW; 86CFF2DE29CA10A9 CRC64;
MNPIDTDDLE KHTPMMRQYL TMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
GKSGGDPIPM AGIPYHAVEG YLAKLVQIGQ SVAICEQIGD PATSKGPVER KVVRIVTPGT
LTDEALLQER QDNLLAAVYQ GKVGFGYATL DVSSGRFVIA ELETKESLEA ELQRTNPVEI
LYSEDFDAME LLHHFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIT DARLSLQAAG
CLMQYVKDTQ RTALPHINAI TRFNQTDTIV LDAATRRNLE LTQNLSGGRD NTLAAVLDNT
ATAMGSRMLQ RWIHQPLRDH AQIFARQTAV NELLETTAHE SLHEQLKALG DIERIMARLA
LRTARPRDFA RLRQALNLLP QLQQSLAQLS APHTVKLGQL LGEFPEEQQL LERAIVDNPP
MLIRDGGVIR EGYNAELDEW RGLSEGATDY LVQLEAREKE RTGIATLKVG YNRVHGYYIE
VSRLQSQQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWDELFDLIL
PKLHELQAFA RAAAELDVLS NFAERAETLG YTCPELSSEI GVKIEAGRHP VVERVSQTPF
IANPVTLHNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVSADRAI IGPIDRIFTR
IGASDDLASG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
QQIGAMTLFA THYFELTQLP ELMAGVYNVH LDAIEHEDTI AFMHAVQEGA ASKSYGLQVA
SLAGVPARVI KAAKHKLHQL ESRDHQVEGV NVNGTRAPIQ TLLALPEPVE NPAVSKLKAI
NPDNLTPKQA LDLLYELKRL S