ID   MUTS_SHESW              Reviewed;         856 AA.
AC   A1RHG2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Sputw3181_1264;
OS   Shewanella sp. (strain W3-18-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=351745;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W3-18-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Lykidis A., Tiedje J., Richardson P.;
RT   "Complete sequence of Shewanella sp. W3-18-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000503; ABM24107.1; -; Genomic_DNA.
DR   RefSeq; WP_011788614.1; NC_008750.1.
DR   AlphaFoldDB; A1RHG2; -.
DR   SMR; A1RHG2; -.
DR   GeneID; 45043237; -.
DR   KEGG; shw:Sputw3181_1264; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002597; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008100"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95475 MW;  95BCE7F2D7BFDA02 CRC64;
     MNVIDTDDLE KHTPMMRQYL TMKAEHHDML LFYRMGDFYE LFYDDAKRAS ELLGISLTAR
     GKSGGDPIPM AGIPYHAVEG YLAKLVQIGQ SVAICEQIGD PATAKGPVER KVVRIVTPGT
     LTDEALLQER QDNLLAAVYQ GKVGFGYATL DVSSGRFVIA ELDTKESLEA ELQRTNPVEI
     LYSEDFGELG LLSHFKGKRR RPEWEFDYDT SIKLLLAQFG TKDLHGFGIS DARLSLQAAG
     CLMQYVKDTQ RTTLPHINAI IRFNQADSIV LDAATRRNLE LTQNLAGGRD NTLAAVLDNT
     ATAMGSRMLQ RWIHQPLRDP NQIIARQTAV NELLKTGTHE PLHEQLKALG DIERIMARLA
     LRTARPRDFA RLRQALSLLP ELQQSLSVLN APHTVKLCQY LGEFPEEQAL LERAIVDNPP
     MLIRDGGVIR EGYNNELDEW RGLSEGASDY LVQLEAREKE RTGINTLKVG YNRVHGYYIE
     VSRLQSSQVP LNYQRRQTLK NMERYITPEL KEYEEKVLSS QGKALALEKQ LWEQLFDLIL
     PKLHELQAFA RAAAELDVLS NFAERAETLG YICPQLSQDI GVQIDAGRHP VVERVSQTPF
     IANPVTLHNQ RRMLIVTGPN MGGKSTYMRQ VALITLMAHI GCFVPAERAV IGPIDRIFTR
     IGASDDLASG RSTFMVEMTE TANILHNATA QSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QQIGAMTLFA THYFELTQLP DLMAGVYNVH LDAIEHEDTI AFMHAVQEGA ASKSYGLQVA
     ALAGVPAKVI KAAKHKLQQL ESRDHQLEGT KTPIQTLLAL PEPAENPALT KLQAINPDNL
     TPKQALDLLY ELKRLS