ID   MUTS_SHEWM              Reviewed;         858 AA.
AC   B1KPS7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Swoo_3341;
OS   Shewanella woodyi (strain ATCC 51908 / MS32).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=392500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51908 / MS32;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella woodyi ATCC 51908.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000961; ACA87610.1; -; Genomic_DNA.
DR   RefSeq; WP_012325945.1; NC_010506.1.
DR   AlphaFoldDB; B1KPS7; -.
DR   SMR; B1KPS7; -.
DR   STRING; 392500.Swoo_3341; -.
DR   EnsemblBacteria; ACA87610; ACA87610; Swoo_3341.
DR   KEGG; swd:Swoo_3341; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002168; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093646"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95444 MW;  6A606B85969E3B21 CRC64;
     MKAIDSQDLE KHTPMMRQYL TLKAENPDVL LFYRMGDFYE LFYDDAKKAS ELLGISLTAR
     GKSGGDPIPM AGLPYHAVEG YLAKLVQLRV SVAICEQVGD PATSKGPVER KVVRLVTPGT
     LTDEALLQER QDNLLAAVYH GKKGFGYATL DISSGRFVIA ELESCEALEA ELQRTSPAEL
     LYSEDFSEMS LISAFEGTRR RPEWEFDFDT SQKLLLDQFG TKDLQGFGLD GARLSLQAAG
     CLMQYVKDTQ RTALPHINSI VRFNQGDSII LDAATRRNLE LTMNLQGGHS NTLATVLDNT
     TTPMGSRMLQ RWIHEPLRDR QRIEARQSAL EEILENGLYD ELHPLLKSLG DVERITARLA
     LRNARPRDFS RLKHALAILP EIQQILARCQ SAHLQSLARI ISEFPEELAL LDSAIVDNPP
     MLIRDGGVLK PGYNAELDQW RDLSQGATDY LAELEAREKE ATGISTLKVG YNRVHGYYIE
     VSRRESDLVP LSYQRRQTLK NTERYIVAEL KEHEEKVLSS QGKALALEKQ LWDQLFDLIL
     PQLHELQLFA QGAAELDVLA NFAERADTLN YQRPVLTDIP GIQIESGRHP VIEQVSQTPF
     IANPVTLSPA RKMLIVTGPN MGGKSTYMRQ VALITLMAHI GCYVPAQSAT IGPVDRIFTR
     IGAADDLASG RSTFMVEMTE TANILHNATP KSLVLMDEIG RGTSTYDGLS LAWSAAEYLA
     QKIEAMTLFA THYFELTQLP ELISNVANVH LDAIEHGDTI VFMHAVQDGA ASKSYGLQVA
     ALAGVPNPVI LAAKHKLHHL ESRDNHNTQQ TDSSGVQQSM VFPDPIKSPL EEAMESIRPD
     ELSPKQALDI LYRLKDLS