ID   MUTS_SINMW              Reviewed;         915 AA.
AC   A6U5G0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Smed_0030;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000738; ABR58890.1; -; Genomic_DNA.
DR   RefSeq; WP_011974245.1; NC_009636.1.
DR   RefSeq; YP_001325725.1; NC_009636.1.
DR   AlphaFoldDB; A6U5G0; -.
DR   SMR; A6U5G0; -.
DR   STRING; 366394.Smed_0030; -.
DR   EnsemblBacteria; ABR58890; ABR58890; Smed_0030.
DR   KEGG; smd:Smed_0030; -.
DR   PATRIC; fig|366394.8.peg.3084; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..915
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008102"
FT   BINDING         665..672
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   915 AA;  99239 MW;  D80D873F86BA7395 CRC64;
     MNFLMDASNR TGDVLSVSDL ASEESRSTAT PMMEQFIEIK ANNRDSLLFY RMGDFYELFF
     QDAVEASRAL GITLTKRGQH MGQEIPMCGV PVHAADDYLQ KLIALGYRVA VCEQVEDPAE
     AKKRGGKSVV RRDVVRLVTP GTITEDKLLS PSESNYLMAL ARIRSGSEPA YALAWIDIST
     GIFRLAETAE SRLLADILRI EPRELILPDT VFHDPDLRPV FDVLGRVAVP QPAILFDSAT
     AEGRISRYYG VGTLDGFGSF SRAELAAASA AVSYVEKTQL QERPALGIPE RESAASTLFI
     DPATRANLEL AKTLSGSRDG SLLKSLDRTV TSGGARLLAE RLMSPLTDPE RINRRLDSIE
     MLADQPRFTA DARDALRRAP DMPRALSRLA LGRGGPRDLG AIQAGMRAAV AIAALLSGAE
     LSVELAEARD AIAGLPRDLL ARLDATLAEE LPLLKRDGGF VREGANAELD EMRALRDQSR
     RVVAGLQLQY CEETGIKSLK IKHNNVLGYF IEVTAGNAGA MIDTDAGRAR FIHRQTMANA
     MRFTTTELAE LETKIANAAD RVLAIELETF EVMTREVVAE AEAIKAAALA LATIDVSAGL
     AVLAEEQNYT RPAVDRSRMF AIDGGRHPVV EQALRRQAAN PFVANGCDLS PPGGEEGGAI
     WLLTGPNMGG KSTFLRQNAL IAIMAQMGSF VPASAAHIGV VDRLFSRVGA SDDLARGRST
     FMVEMVETAA ILNQATDRSL VILDEIGRGT ATFDGLSIAW AAVEHLHEVN RCRGLFATHF
     HELTVLSEKL GRLSNATMRV KEWDGDVIFL HEVGPGAADR SYGIQVARLA GLPASVVARA
     RDVLAKLEDA DRKNPASQLI DDLPLFQVAV RREEAARAPG LSRAEEALKA LNPDDMTPRE
     ALDALYALKK QLSNR