ID   MUTS_SODGM              Reviewed;         854 AA.
AC   Q2NVL9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SG0531;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008232; BAE73806.1; -; Genomic_DNA.
DR   RefSeq; WP_011410504.1; NZ_LN854557.1.
DR   AlphaFoldDB; Q2NVL9; -.
DR   SMR; Q2NVL9; -.
DR   STRING; 343509.SG0531; -.
DR   EnsemblBacteria; BAE73806; BAE73806; SG0531.
DR   KEGG; sgl:SG0531; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; SGLO343509:SGP1_RS04685-MON; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008103"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  94890 MW;  1EEA03790E7FE046 CRC64;
     MIDTKNLDSH TPMMQQYLKL KAQHPDILLF YRMGDFYELF YDDAKRASQL MDISLTKRGA
     SAGQPIPMAG VPYHAVENYL AKLVALGESV AICEQIGDPA TTKGPVERRV VRIVTPGTLS
     DEALLNERQD NLLAALWQAP QGFGYATLDI TSGRFLVSEP ADREAMAAEL QRTNPAELLY
     PETLQDMKLI EHRRGQRRRP LWEFELDTAR QQLTLQFGTR DLNGFGIERA QLALRAAGCL
     LQYAKDTQRT SLPHIRAVTL ELQQDGIVMD AATRRNLELT QNLSGGGENT LADVLDRTVT
     PMGSRMLKRW LHMPTRDITT LTYRQQSIRA LQDHVAELQP LLRQVGDLER VLARLALRSA
     RPRDLARMRY AFTQLPAIQA LLCGQSEPYL PQLLDRVGEF ETLRDLLARA IIEAPPVLVR
     DGGVIAPGYH AELDEWRGLA AGATDYLDRL ELREREKTGL ETLKVGFNAV HGYFIQLSRG
     QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKSKA LALEKALYDE LFDLLLPHLA
     ALQQSATALA ELDVLSNLAE RAETLRYVCP TIDARQGIHI SGGRHPVVEH VLSEPFIANP
     LTLSDARRML IITGPNMGGK STYMRQTALI VLLAYIGSFV PADEATIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATHQSLV LMDEIGRGTS TYDGLSLAWA SAESLAGRIK
     AMTLFATHYF ELTTLPEKME GVVNVHLDAV EHGDTIAFMH SVQEGAASKS YGLSVAALAG
     VPREVIKRAR QKLRELETLS TGAAAGSVDG SQLSLLQPEE QPVAPAVEAL ENLDPDSLSP
     RQALEWLYRL KKML