ID   MUTS_SOLUE              Reviewed;         869 AA.
AC   Q01X96;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Acid_4760;
OS   Solibacter usitatus (strain Ellin6076).
OC   Bacteria; Acidobacteria; Bryobacterales; Solibacteraceae;
OC   Candidatus Solibacter.
OX   NCBI_TaxID=234267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin6076;
RX   PubMed=19201974; DOI=10.1128/aem.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000473; ABJ85719.1; -; Genomic_DNA.
DR   RefSeq; WP_011686469.1; NC_008536.1.
DR   AlphaFoldDB; Q01X96; -.
DR   SMR; Q01X96; -.
DR   STRING; 234267.Acid_4760; -.
DR   EnsemblBacteria; ABJ85719; ABJ85719; Acid_4760.
DR   KEGG; sus:Acid_4760; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335226"
FT   BINDING         624..631
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  96583 MW;  1EE902652D342915 CRC64;
     MSDASTPLMR QYNSIKEQVP NALLMFRLGD FYELFFEDAV TAARELEITL TARNKEKGNA
     IPMCGVPYHA AEGYISRLIQ KGFRVAICDQ VEDAKLAKKL VRREITRVVT PGTAMDSNLV
     RSRENNFLAA VGRSGSRSAV AHVDVSTGEF RVTEMEPEEV AGALEHLGAR EVLFPGDLPL
     LTGEDRSGLR FVRTELEDWV FTHDYSDRTL RDHFKLLSLD GCGLANRAAA IGAAGAILHY
     LRDTQRAALD HLDRPTYYDR ADSMVLDSVT VRNLELIEPL FAADAGGIHA QPTVLGVLDQ
     TLTGMGGRLL RQRLLRPSMN RAEIEQRLDA VGELQQQTIL RAELRKQLSG ILDLERLLAK
     VTLGSAGPRD VLALGRSLEK IPALKRCFDT QQAARLRNLH DRLDELADVA SLILDCISDE
     PPLNLVDGGT IRAGFHPELD ELRDLSQNGK QYIAQIEARE RQRTGIGSLK VRFNNVFGYY
     IEITRANQHL APADYERKQT LANAERFTTP ELKDYERKVL DAEDKILTLE KELFSDVRKR
     AAAHAQRIRA AAAAVAELDV TASLAQVAAE NRYQRPCFSD SGEMRIMAGR HPVIERLTEQ
     EAGRFIPNDL YLNDSTDLLA IITGPNMGGK STYLRQAALI AILAQIGSFV PAESASLPVI
     DRIFTRIGAS DNLARGRSTF MVEMTETAVI LNTATPRSFI VLDEVGRGTA TYDGLALAWA
     VVEYIHQRTR AKTLFATHYH ELTELAEQLS GVRNLMVSVK EAGDHIIFLR KVEPGKADRS
     YGIEVARLAG LPISVIERAR DVLKLHERTE HAVSGELVKS EDHGPVQIQM FEPVGYGIAE
     RIRAINVDEL RPIEALQLLS ELQKELKRS