ID   MUTS_SORC5              Reviewed;         918 AA.
AC   A9GIM9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=sce3129;
OS   Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS   ce56)).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Sorangiineae;
OC   Polyangiaceae; Sorangium.
OX   NCBI_TaxID=448385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=So ce56;
RX   PubMed=17965706; DOI=10.1038/nbt1354;
RA   Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA   Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA   Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA   Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA   Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA   Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA   Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA   Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA   Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA   Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA   Puehler A., Mueller R.;
RT   "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL   Nat. Biotechnol. 25:1281-1289(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM746676; CAN93288.1; -; Genomic_DNA.
DR   RefSeq; WP_012235760.1; NC_010162.1.
DR   AlphaFoldDB; A9GIM9; -.
DR   SMR; A9GIM9; -.
DR   STRING; 448385.sce3129; -.
DR   EnsemblBacteria; CAN93288; CAN93288; sce3129.
DR   KEGG; scl:sce3129; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; SCEL448385:SCE_RS16035-MON; -.
DR   Proteomes; UP000002139; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..918
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335227"
FT   BINDING         662..669
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   918 AA;  97551 MW;  B36868B4238D15B0 CRC64;
     MQPSEQPAAR KKLTPVMRQY EDAKALHPDA ILFFRMGDFY EMFNDDAVLV SRALNLTLTS
     RNKGEPDESP MAGVPHHAAH GYIARLLALG HKVAICEQCG DPSKIKGLVP RQVVRVVTPG
     LVTETEQLDA RANHYLAAVD GGGAPRGDAL GAGGPYGLSL LDLSTGELSA TSVPDAATLL
     AELARADPRE ALIARDLPDV RAAAASLACR AALRDDEELD SAHVASILDD AAIEPISAAA
     LAEHPLPAVR AAARALRFAR RCSPGARIPV RRIAPHDTSG TLRIDETAQA HLELVRAADG
     GRRGTLLDVI DCTVTPGGAR LLRRRLLSPL ADLAGIRRRL DEVELFVSHP RARGELRQAL
     GGVGDLERLS VRALLGEATP RDLGLLRDGL TAAPAAIAAV RSIPDLGKAA ARSDDGAAAR
     GKDGAAAGSS SGSEPLLAEA AALDVVADVC AELTAALIER PPPNTREGGI FREGYDKELD
     DARGVEKNAT ELILALEAKL RTQTGAPSLR VKYTRVFGWY IEVTRAHIAK VPETFRRKQT
     VATGERYTSD ELDELADKIE HAGARALERE TALFDRLRAL VAKSEGRLRA LARKLAAWDV
     AAALADVAHR NDYVRPHVTA GEALAIRDGR HPVVERYAAA GHFVPNDTRL DLSGERLWLI
     TGPNMAGKST LMRQVALIVV LAQMGSYVPA REAEIGLVDR ILSRVGASDN VARGESTFMV
     EMRETAEILR DATRRSLVIL DEIGRGTSTY DGLAIAWAVA EHLFDAIGCR ALFATHYHEL
     TELSARAPGI ANYSVAAREH GDDVIFLHKL EAGPASRSYG VAVARLAGVP EGVLARARAI
     LATLESGAAL PGGKHASLRG RTRGGAAQLD LFAPAQAAVP PEQSAVIETL RAVDVDRLAP
     LDALRLVAKL KGLLGGGG