MUTS_STAA8
ID MUTS_STAA8 Reviewed; 872 AA.
AC Q2FYZ9; Q7WRG7; Q7WYI7; Q932P9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS; OrderedLocusNames=SAOUHSC_01272;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA O'Neill A.J., Chopra I.;
RT "Mismatch repair in Staphylococcus aureus.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12384362; DOI=10.1128/aac.46.11.3540-3548.2002;
RA Schaaff F., Reipert A., Bierbaum G.;
RT "An elevated mutation frequency favors development of vancomycin resistance
RT in Staphylococcus aureus.";
RL Antimicrob. Agents Chemother. 46:3540-3548(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Muthaiyan A., Jayaswal R.K., Wilkinson B.J.;
RT "Intact mutS gene in laboratory-derived and clinical glycopeptide-
RT intermediate Staphylococcus aureus strains.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABD30373.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF378369; AAK56305.1; -; Genomic_DNA.
DR EMBL; AJ296342; CAC44463.1; -; Genomic_DNA.
DR EMBL; AY324086; AAP87081.1; -; Genomic_DNA.
DR EMBL; CP000253; ABD30373.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000073353.1; NZ_LS483365.1.
DR RefSeq; YP_499805.1; NC_007795.1.
DR AlphaFoldDB; Q2FYZ9; -.
DR SMR; Q2FYZ9; -.
DR STRING; 1280.SAXN108_1300; -.
DR EnsemblBacteria; ABD30373; ABD30373; SAOUHSC_01272.
DR GeneID; 3919925; -.
DR KEGG; sao:SAOUHSC_01272; -.
DR PATRIC; fig|93061.5.peg.1166; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_2_9; -.
DR PRO; PR:Q2FYZ9; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..872
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000247941"
FT BINDING 602..609
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 872 AA; 99903 MW; FF9AC32A82EFD590 CRC64;
MSNVTPMMQQ YLKIKSEYQD CLLFFRLGDF YEMFYEDAKE ASRVLEITLT KRDAKKENPI
PMCGVPYHSA DSYIDTLVNN GYKVAICEQM EDPKQTKGMV RREVVRIVTP GTVMEQGGVD
DKQNNYILSF VMNQPEIALS YCDVSTGELK VTHFNDEATL LNEITTINPN EVVINDNISD
NLKRQINMVT ETITVRETLS SEIYSVNQTE HKLMYQATQL LLDYIHHTQK RDLSHIEDVV
QYAAIDYMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLISK
EQIEARLDIV DEFSAHFIER DTLRTYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
PNIKALLNSM NQNTLVQVNQ LEPLDDLLDI LEQSLVEEPP ISVKDGGLFK VGFNTQLDEY
LEASKNGKTW LAELQAKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQNFE PSEFGYMRKQ
TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE EVKKYTERLQ QQAKIISELD
CLQSFAEIAQ KYNYTRPSFS ENKTLELVES RHPVVERVMD YNDYVPNNCR LDNETFIYLI
TGPNMSGKST YMRQVAIISI MAQMGAYVPC KEAVLPIFDQ IFTRIGAADD LVSGKSTFMV
EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAETSHAK TLFSTHYHEL
TTLDQALPSL KNVHVAANEY KGELIFLHKV KDGAVDDSYG IQVAKLADLP EKVISRAQVI
LSEFEASAGK KSSISNLKMV ENEPEINQEN LNLSVEETTD TLSQKDFEQA SFDLFENDQK
SEIELQIKNL NLSNMTPIEA LVKLSELQNQ LK
