ID   MUTS_STAAB              Reviewed;         872 AA.
AC   Q2YXR9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SAB1157;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AJ938182; CAI80846.1; -; Genomic_DNA.
DR   RefSeq; WP_000073333.1; NC_007622.1.
DR   AlphaFoldDB; Q2YXR9; -.
DR   SMR; Q2YXR9; -.
DR   KEGG; sab:SAB1157; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008105"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  99974 MW;  E3721B911A6BA598 CRC64;
     MSNVTPMMQQ YLKIKSEYQD CLLFFRLGDF YEMFYEDAKE ASRVLEITLT KRDAKKENPI
     PMCGVPYHSA DSYIDTLVNN GYKVAICEQM EDPKQTKGMV RREVVRIVTP GTVMEQGGVD
     DKQNNYILSF VMNQPEIALS YCDVSTGELK VTHFNDEATL LNEITTINPN EVVINDNISD
     HLKRQINMVT ETITVRETLS SEIYSVNQTE HKLMFQATQL LLDYIHHTQK RDLSHIEDVV
     QYAAIDYMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLISK
     EQIEARLDIV DEFSAHFIER DTLRTYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
     PNIKALLNSM NQDTLVQVNQ LEPLDDLLDI LEQSLVEEPP ISVKDGGLFK VGFNMQLDEY
     LEASKNGKTW LAELQAKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQNFE PSEFGYMRKQ
     TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE EVKKYTERLQ QQAKIISELD
     CLQSFAEIAQ KYNYTRPSFS ENKTLELVES RHPVVERVMD YNDYVPNNCR LDNETFIYLI
     TGPNMSGKST YMRQVAIISI MAQMGAYVPC KEAVLPIFDQ IFTRIGAADD LVSGKSTFMV
     EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAETSHAK TLFSTHYHEL
     TTLDQALPSL KNVHVAANEY KGELIFLHKV KDGAVDDSYG IQVAKLADLP EKVISRAQVI
     LSEFEASADK KSSISNLKMV ENEPEINQEN SNLSVEETTD TLSQKDFEQA SFDLFENDQE
     SEIELQIKNL NLSNMTPIEA LVKLSELQNQ LK