ID   MUTS_STAAE              Reviewed;         872 AA.
AC   A6QGJ4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NWMN_1204;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP009351; BAF67476.1; -; Genomic_DNA.
DR   RefSeq; WP_000073352.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QGJ4; -.
DR   SMR; A6QGJ4; -.
DR   EnsemblBacteria; BAF67476; BAF67476; NWMN_1204.
DR   KEGG; sae:NWMN_1204; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071279"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  99904 MW;  F738490A82EFD590 CRC64;
     MSNVTPMMQQ YLKIKSEYQD CLLFFRLGDF YEMFYEDAKE ASRVLEITLT KRDAKKENPI
     PMCGVPYHSA DSYIDTLVNN GYKVAICEQM EDPKQTKGMV RREVVRIVTP GTVMEQGGVD
     DKQNNYILSF VMNQPEIALS YCDVSTGELK VTHFNDEATL LNEITTINPN EVVINDNISD
     NLKRQINMVT ETITVRETLS SEIYSVNQTE HKLMYQATQL LLDYIHHTQK RDLSHIEDVV
     QYAAIDYMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLISK
     EQIEARLDIV DEFSAHFIER DTLRTYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
     PNIKALLNSM NQNTLVQVNQ LEPLDDLLDI LEQSLVEEPP ISVKDGGLFK VGFNTQLDEY
     LEASKNGKTW LAELQAKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQNFE PSEFGYMRKQ
     TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE EVKKYTERLQ QQAKIISELD
     CLQSFAEIAQ KYNYTRPSFS ENKTLELVES RHPVVERVMD YNDYVPNNCR LDNETFIYLI
     TGPNMSGKST YMRQVAIISI MAQMGAYVPC KEAVLPIFDQ IFTRIGAADD LVSGKSTFMV
     EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAETSHAK TLFSTHYHEL
     TTLDQALPSL KNVHVAANEY KGELIFLHKV KDGAVDDSYG IQVAKLADLP EKVISRAQVI
     LSEFEASAGK KSSISNLKMV ENEPEINQEN LNLSVEETTD TLSQKDFEQA SFDLFENDQE
     SEIELQIKNL NLSNMTPIEA LVKLSELQNQ LK