ID   MUTS_STACT              Reviewed;         869 AA.
AC   B9DPB9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Sca_0945;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM295250; CAL27853.1; -; Genomic_DNA.
DR   RefSeq; WP_015900194.1; NC_012121.1.
DR   AlphaFoldDB; B9DPB9; -.
DR   SMR; B9DPB9; -.
DR   STRING; 396513.SCA_0945; -.
DR   GeneID; 60545362; -.
DR   KEGG; sca:SCA_0945; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; SCAR396513:SCA_RS04755-MON; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192202"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  99593 MW;  8D3EDB16103E5933 CRC64;
     MTNVTPMMQQ YLKIKSQYQD CLLFFRLGDF YEMFFEDAKE ASRVLEITLT KRDAKKENPI
     PMCGVPYHSA ESYIETLINE GYKVAICEQM EDPKTTKGMV KREVIRVVTP GTIMNQGGMD
     EKQNNYILSF IKDGATIAVS YCDVSTGELK VTKFNDESML LNEITTINPN EIVAADQVSE
     SLKQQMSLAT ETITVVDEIS NEAYEVNQVE DTLMHQAVQL LLDYIHHTQK RNMNHIEDAQ
     VYEAIDYMKM DYYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLIYK
     QAINERLDAV SQLIDRFIER DTLRNYLNQV YDIERLVGRV SYGNVNARDL IQLKHSIAEI
     PNIKALLDDF DDALPEQFRQ LEPLNDLLDL LEKSLVEEPP ISVKDGGLFK QGFNQQLDEY
     LEASVNGKQW LAQLQAKERE RTGIKSLKIS FNKVFGYFIE ITRANLKGFE PADFGYNRKQ
     TLSNAERFIT DELKEKEDII LGAEDKAVEL EYQLFAQLRE EVKAYTERLQ KQAKLISEID
     CLQSFAEIAQ KYNYVRPEFS DDKTLDLVDS RHPVVERVMD YNDYVPNDCR LDDDQFIYLI
     TGPNMSGKST YMRQVAIISI MAQMGAYVPC GSAVLPIFDQ IFTRIGAADD LVSGKSTFMV
     EMLEAQKALT YATEDSLIIF DEIGRGTSTF DGLALAQAMI EYVAETSHAK TLFSTHYHEL
     TTLDQSLECL KNVHVAANEY QGELIFLHKV KDGAVDDSYG IQVAKLADLP DRVIERAQVI
     LDAFEEKDKP QPQISHLQQT ESFVREPEIE DIQDKKEPET EQFQQGAFDL FETPPVESEI
     EAELKKINIS NMTPLQALNK LSELQNQLK