ID   MUTS_STAES              Reviewed;         873 AA.
AC   Q8CPF0;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SE_0974;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015929; AAO04571.1; -; Genomic_DNA.
DR   RefSeq; NP_764529.1; NC_004461.1.
DR   RefSeq; WP_002456219.1; NZ_WBME01000001.1.
DR   AlphaFoldDB; Q8CPF0; -.
DR   SMR; Q8CPF0; -.
DR   STRING; 176280.SE_0974; -.
DR   EnsemblBacteria; AAO04571; AAO04571; SE_0974.
DR   KEGG; sep:SE_0974; -.
DR   PATRIC; fig|176280.10.peg.948; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115142"
FT   BINDING         601..608
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  100777 MW;  332AC9F98B46D3FB CRC64;
     MANITPMMQQ YLKIKSEYDD CLLFFRLGDF YEMFFDDAKE ASRVLEITLT KRDAKKENPI
     PMCGVPYHSA DNYIETLINK GYKVAICEQM EDPKQTKGMV RREVVRIITP GTVMDQNGMD
     EKKNNYILSF IENEEFGLCY CDVSTGELKV THFKDTATLL NEITTINPNE IVIKQALSEE
     LKRQINMITE TITVREDISD EDYDMNQLTH QLMHDTTQLL LDYIHHTQKR DLSHIEEVIE
     YAAVDYMKMD YYAKRNLELT ESIRLKSKKG TLLWLMDETK TPMGARRLKQ WIDRPLINKQ
     QINDRLNIVE EFMDRFIERD TLRNHLNQVY DIERLVGRVS YGNVNARDLI QLKHSISEIP
     HIKALLNELG AQTTTQFKEL EPLDDLLQIL EESLVEEPPI SIKDGGLFKN GFNAQLDEYL
     EASKNGKTWL AELQAKERER TGIKSLKISF NKVFGYFIEI TRANLNNFQP EAFGYNRKQT
     LSNAERFITD ELKEKEDIIL GAEDKAVELE YELFVKLREH IKTYTERLQK QAKIISELDC
     LQSFAEIAQK YNYVKPTFSD DKVLHLENSR HPVVERVMDY NDYVPNDCHL DDETFIYLIT
     GPNMSGKSTY MRQVAIISIM AQMGAYVPCD SATLPIFDQI FTRIGAADDL VSGKSTFMVE
     MLEAQKALTY ATENSLIIFD EIGRGTSTYD GLALAQAMIE YVAQTSHAKT LFSTHYHELT
     SLDQMLKCLK NVHVAANEYQ GELIFLHKVK DGAVDDSYGI QVAKLADLPN EVIDRAQVIL
     NAFEQKPSYQ LSHENTDNQQ TVPSYNDFGR TEEEQSVIET HTSNHNYEQA TFDLFDGYNQ
     QSEVECQIRE LNLSNMTPLE ALIKLNELQS QLK