ID   MUTS_STAHJ              Reviewed;         883 AA.
AC   Q4L5Z9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SH1617;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP006716; BAE04926.1; -; Genomic_DNA.
DR   RefSeq; WP_011275903.1; NC_007168.1.
DR   AlphaFoldDB; Q4L5Z9; -.
DR   SMR; Q4L5Z9; -.
DR   STRING; 279808.SH1617; -.
DR   PRIDE; Q4L5Z9; -.
DR   EnsemblBacteria; BAE04926; BAE04926; SH1617.
DR   KEGG; sha:SH1617; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..883
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224407"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   883 AA;  101125 MW;  DB991F8290AAA5EB CRC64;
     MSNTTPMMQQ YLKIKSQYQD CLLFFRLGDF YEMFFEDAKE ASRVLEITLT KRDAKKENPI
     PMCGVPYHSA NSYIETLINN GYKVAICEQM EDPKQTKGMV KREVVRVVTP GTVMEQGGMD
     ENQNNYILSF IKQDSNYALS YCDISTGELK ATQIEDEDTL INEIVTINPN EIVVNQEIDE
     NLKKQIYLTT ETITIRESIS DASYEVNQLT NNHMYLATQL LLDYVYHTQK RDLSHLETAI
     TYAAVDFMKM DYYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLINK
     ERIEERLSIV ESFMNHFIER DTLRGYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
     PNIKSLLESM NDVASNQFSS LEPLEDLLQV LEDSLIEEPP ISIKDGGLFK QGFSKQLDEY
     LEASKNGKDW LAQLQAKERE RTGIKSLKIS FNKVFGYFIE ITRANLQGFE PSKFGYHRKQ
     TLSNAERFIT DELKEKEDII LGAEDKAVDL EYQLFVRLRE HIKTYTERLQ KQAKIISELD
     CLQSFAEIAQ KYNYVKPEFS DNKTLSLENS RHPVVERVMD YNDYVPNDCK LDKDNFIYLI
     TGPNMSGKST YMRQVAIISI MAQMGAYVPC NKAELPIFDQ IFTRIGAADD LVSGKSTFMV
     EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAQTSHAK TLFSTHYHEL
     TTLDQELPSL KNVHVAADEY QGELIFLHKV KDGAVDDSYG IQVAKLANLP DEVINRAQVI
     LDAFEQSQNT SDNEEHSNIT VLKDSASVEG FTDDDAQNAN NSDKKSQTTK NAIENEFEQA
     SFNLFDSEAM TSEIEEQIKN LNISNMTPIE ALLKLSELQN QLR