ID   MUTS_STAS1              Reviewed;         887 AA.
AC   Q49X88;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=SSP1465;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP008934; BAE18610.1; -; Genomic_DNA.
DR   RefSeq; WP_011303232.1; NZ_MTGA01000034.1.
DR   AlphaFoldDB; Q49X88; -.
DR   SMR; Q49X88; -.
DR   STRING; 342451.SSP1465; -.
DR   EnsemblBacteria; BAE18610; BAE18610; SSP1465.
DR   KEGG; ssp:SSP1465; -.
DR   PATRIC; fig|342451.11.peg.1469; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..887
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224408"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   887 AA;  101236 MW;  C5F60ED6C31D4726 CRC64;
     MTNQTPMMQQ YLKIKSQYQD CLLFFRLGDF YEMFFEDAKV ASRVLEITLT KRDAKKEDPI
     PMCGVPYHSA DGYIETLISN GYKVAICEQM EDPRQTKGMV RREVVRIVTP GTVMDQGGVD
     EKQNNYILSF IQSASMYALS YCDVSTGELK VTHFEDEATL INEITTINPN EIVVKEAIGE
     SLKRQISLTT ETITVLPDIS DVKYDVNTTN DSHLYHVTQL LLDYVYHTQK RDLSHIESVI
     TYEAVDFMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLIQK
     KQIESRLDTV DQFINHFIER DTLRGYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
     PNIKNLLQAF DEQMTAQFEA LEPLDDLLNL LEESLKEEPP ISVKEGGLFK TGFNETLDSY
     LEASKNGKNW LAELQTKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQGFD PTEFGYHRKQ
     TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE QIKAYTERLQ KQAKVISELD
     CLQSFAEIAQ KYNYARPTFS EDKTLELVNS RHPVVERVMD HNDYVPNDCE LDKETFIYLI
     TGPNMSGKST YMRQVAIISI MAQMGAYVPC ESAILPVFDQ IFTRIGAADD LVSGKSTFMV
     EMLEAQKALA HATEHSLIIF DEIGRGTSTY DGLALAQAMI EYVAHTSHAK TLFSTHYHEL
     TTLDQSLACL KNVHVAANEY NGELIFLHKV KDGAVDDSYG IQVAKLAHLP VEVINRVQVI
     LDAFEQSNNQ TNNKNTMNHV DIPTDKNLNA SSDEVTEIKA TYYVDNEQSA ATQHAKSDGQ
     FEQAAFDLFD SPAKQSEIEN EIKTLNLSNM TPIEALVKLS ELQKQLK